378
Participants
Start Date
August 31, 2003
Primary Completion Date
January 1, 2010
Study Completion Date
March 31, 2016
filgrastim
Given IV or SC (5mcg/kg/day) start on Day 3 and continue until ANC \>1500/μl given subcutaneously or intravenously.
carboplatin
Given IV (375 mg/m2/day) Day 1 given as an IV infusion over one hour. For patients with BSA \<0.45m2 the dose is 12.5 mg/kg/day.
cyclophosphamide
Given IV (1000mg/m2/day) Day 1 and 2 given as an IV infusion over one hour following carboplatin administration. For patients with BSA\<0.45m2 the dose is 33mg/kg/day on Day 1 and 2.
etoposide
Given orally (50 mg/m2/day) orally once daily on Days 1 through 21. For patients with BSA \< 0.45 m2, the dosage is 1.7 mg/kg/day on Days 1 through 21.
vincristine sulfate
Given IV or orally (1.5mg/m2/day) (maximum dose 2 mg) Day 1 and 8 given as IV bolus. For patients with BSA\<0.45m2 the dose is 0.05mg/kg.
radiation therapy
Given once daily 5 days a week for 6-6½ weeks
Mesna
Mesna (200mg/m2/dose) Day 1 and 2. For patients with BSA\<0.45m2 the dose is (7mg/kg/dose). Combine mesna (200mg/m2) with cyclophosphamide and administer intravenously over one hour followed by mesna (200mg/m2) in 375 cc/m2 D5-1/2NS and run intravenously over 3 hours at 125cc/m2/hr. After 3 hour mesna, administer mesna (200 mg/m2/dose) IV over 15 minutes at hour 5.
therapeutic conventional surgery
Starship Children's Health, Auckland
Swiss Pediatric Oncology Group Lausanne, Lausanne
Swiss Pediatric Oncology Group Geneva, Geneva
Prince of Wales Private Hospital, Randwick
Westmead Institute for Cancer Research at Westmead Hospital, Westmead
John Hunter Hospital, Newcastle
Swiss Pediatric Oncology Group Bern, Bern
Royal Children's Hospital, Parkville
Royal Children's Hospital, Herston, Brisbane
Women's and Children's Hospital, North Adelaide
Princess Margaret Hospital for Children, Perth
NYU Cancer Institute at New York University Medical Center, New York
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York
Albert Einstein Cancer Center at Albert Einstein College of Medicine, The Bronx
New York Medical College, Valhalla
Schneider Children's Hospital, New Hyde Park
SUNY Upstate Medical University Hospital, Syracuse
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester
Children's Hospital of Pittsburgh, Pittsburgh
Alfred I. duPont Hospital for Children, Wilmington
Carilion Cancer Center of Western Virginia, Roanoke
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division, Charleston
Edwards Comprehensive Cancer Center at Cabell Huntington Hospital, Huntington
Duke Comprehensive Cancer Center, Durham
Hollings Cancer Center at Medical University of South Carolina, Charleston
Greenville Hospital System Cancer Center, Greenville
Winship Cancer Institute of Emory University, Atlanta
Nemours Children's Clinic, Jacksonville
Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola
Nemours Children's Clinic - Orlando, Orlando
Miami Children's Hospital, Miami
Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach
St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa
All Children's Hospital, St. Petersburg
Lee Cancer Care of Lee Memorial Health System, Fort Myers
Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham, Birmingham
T.C. Thompson Children's Hospital, Chattanooga
East Tennessee Children's Hospital, Knoxville
St. Jude Children's Research Hospital, Memphis
Kosair Children's Hospital, Louisville
Toledo Hospital, Toledo
Medical University of Ohio Cancer Center, Toledo
Cleveland Clinic Taussig Cancer Center, Cleveland
Tod Children's Hospital, Youngstown
St. Vincent Indianapolis Hospital, Indianapolis
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods
Hurley Medical Center, Flint
Breslin Cancer Center at Ingham Regional Medical Center, Lansing
Blank Children's Hospital, Des Moines
Midwest Children's Cancer Center, Milwaukee
Marshfield Clinic - Marshfield Center, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota Cancer Center at University of Minnesota, Minneapolis
Mayo Clinic Cancer Center, Rochester
CCOP - MeritCare Hospital, Fargo
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood
Advocate Christ Medical Center, Oak Lawn
Rush University Medical Center, Chicago
Children's Memorial Hospital - Chicago, Chicago
Saint Jude Midwest Affiliate, Peoria
Cardinal Glennon Children's Hospital, St Louis
Siteman Cancer Center at Barnes-Jewish Hospital, St Louis
Children's Mercy Hospital, Kansas City
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock
Oklahoma University Cancer Institute, Oklahoma City
Medical City Dallas Hospital, Dallas
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas
Cook Children's Medical Center - Fort Worth, Fort Worth
CCOP - Scott and White Hospital, Temple
Driscoll Children's Hospital, Corpus Christi
Children's Hospital of Austin, Austin
Texas Tech University Health Sciences Center School of Medicine - Amarillo, Amarillo
Covenant Children's Hospital, Lubbock
Childrens Hospital Los Angeles, Los Angeles
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
UCSF Comprehensive Cancer Center, San Francisco
Stanford Comprehensive Cancer Center - Stanford, Stanford
Children's Hospital & Research Center Oakland, Oakland
Sutter Cancer Center, Sacramento
University of California Davis Cancer Center, Sacramento
Kaiser Permanente Medical Center - Oakland, Sacramento
Cancer Research Center of Hawaii, Honolulu
Legacy Emanuel Hospital and Health Center & Children's Hospital, Portland
Children's Hospital and Regional Medical Center - Seattle, Seattle
Phoenix Children's Hospital, Phoenix
Southern California Permanente Medical Group, Downey
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles
Children's Hospital Central California, Madera
Children's Hospital and Health Center - San Diego, San Diego
Children's Hospital Cancer Center, Denver
Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington
Children's National Medical Center, Washington D.C.
University of Florida Shands Cancer Center, Gainesville
Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando
MBCCOP - Medical College of Georgia Cancer Center, Augusta
St. Luke's Mountain States Tumor Institute - Boise, Boise
University of Chicago Cancer Research Center, Chicago
Advocate Lutheran General Cancer Care Center, Park Ridge
Southern Illinois University School of Medicine, Springfield
Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington
CancerCare of Maine at Eastern Maine Medial Center, Bangor
Maine Children's Cancer Program at Barbara Bush Children's Hospital, Scarborough
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Floating Hospital for Children at Tufts - New England Medical Center, Boston
Massachusetts General Hospital, Boston
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston
C.S. Mott Children's Hospital at University of Michigan Medical Center, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
Spectrum Health Hospital - Butterworth Campus, Grand Rapids
CCOP - Kalamazoo, Kalamazoo
University of Mississippi Cancer Clinic, Jackson
Children's Hospital, Omaha
Sunrise Hospital and Medical Center, Las Vegas
Hackensack University Medical Center Cancer Center, Hackensack
Overlook Hospital, Morristown
Saint Peter's University Hospital, New Brunswick
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick
St. Joseph's Hospital and Medical Center, Paterson
University of New Mexico Cancer Research and Treatment Center, Albuquerque
Albany Medical Center Hospital, Albany
Roswell Park Cancer Institute, Buffalo
Memorial Sloan - Kettering Cancer Center, New York
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte
Wake Forest University Comprehensive Cancer Center, Winston-Salem
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Rainbow Babies and Children's Hospital, Cleveland
Columbus Children's Hospital, Columbus
Children's Medical Center - Dayton, Dayton
Geisinger Medical Center, Danville
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey
Children's Hospital of Philadelphia, Philadelphia
St. Christopher's Hospital for Children, Philadelphia
Rhode Island Hospital Comprehensive Cancer Center, Providence
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls
Vanderbilt-Ingram Cancer Center, Nashville
Baylor University Medical Center - Houston, Houston
M. D. Anderson Cancer Center at University of Texas, Houston
Methodist Children's Hospital of South Texas, San Antonio
Primary Children's Medical Center, Salt Lake City
Fletcher Allen Health Care - University Health Center Campus, Burlington
INOVA Fairfax Hospital, Falls Church
Children's Hospital of The King's Daughters, Norfolk
Naval Medical Center - Portsmouth, Portsmouth
Virginia Commonwealth University Massey Cancer Center, Richmond
Providence Cancer Center at Sacred Heart Medical Center, Spokane
St. Vincent Hospital Regional Cancer Center, Green Bay
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
Children's & Women's Hospital of British Columbia, Vancouver
CancerCare Manitoba, Winnipeg
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Children's Hospital of Western Ontario, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
Hopital Sainte Justine, Montreal
Allan Blair Cancer Centre at Pasqua Hospital, Regina
Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon
Centre Hospitalier Universitaire de Quebec, Québec
University Medical Center Groningen, Groningen
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK