NCT00027820 - Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer | Biotech Hunter

Enrollment

106

Participants

Timeline

Start Date

August 31, 2001

Primary Completion Date

September 30, 2004

Study Completion Date

September 5, 2004

Conditions

Adult Acute Myeloid Leukemia in RemissionChildhood Acute Lymphoblastic Leukemia in RemissionChildhood Acute Myeloid Leukemia in RemissionChildhood Myelodysplastic SyndromeChildhood Renal Cell CarcinomaChronic Myelomonocytic LeukemiaClear Cell Renal Cell Carcinomade Novo Myelodysplastic SyndromeMetastatic Renal Cell CancerPreviously Treated Myelodysplastic SyndromeProgression of Multiple Myeloma or Plasma Cell LeukemiaRecurrent Adult Acute Lymphoblastic LeukemiaRecurrent Adult Acute Myeloid LeukemiaRecurrent Adult Hodgkin LymphomaRecurrent Adult Lymphoblastic LymphomaRecurrent Adult Non-Hodgkin LymphomaRecurrent Childhood Acute Lymphoblastic LeukemiaRecurrent Childhood Acute Myeloid LeukemiaRecurrent Childhood Lymphoblastic LymphomaRecurrent Childhood Non-Hodgkin LymphomaRefractory AnemiaRefractory Anemia With Ringed SideroblastsRefractory Childhood Hodgkin LymphomaRefractory Chronic Lymphocytic LeukemiaRenal Medullary CarcinomaType 1 Papillary Renal Cell CarcinomaType 2 Papillary Renal Cell CarcinomaUntreated Adult Acute Lymphoblastic LeukemiaUntreated Adult Acute Myeloid LeukemiaUntreated Childhood Acute Lymphoblastic Leukemia

Interventions

DRUG

Fludarabine Phosphate

Given IV

RADIATION

Total-Body Irradiation

Undergo TBI

PROCEDURE

Peripheral Blood Stem Cell Transplantation

Undergo nonmyeloablative PBSCT

PROCEDURE

Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation

Undergo nonmyeloablative PBSCT

DRUG

Cyclosporine

Given PO

DRUG

Mycophenolate Mofetil

Given PO

Trial Locations (10)

10126

University of Torino, Torino

30322

Emory University/Winship Cancer Institute, Atlanta

53226

Froedtert and the Medical College of Wisconsin, Milwaukee

75042

Baylor Medical Center at Garland, Garland

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85724

University of Arizona Health Sciences Center, Tucson

94305

Stanford University Hospitals and Clinics, Stanford

97239

OHSU Knight Cancer Institute, Portland

98109

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle

D-04103

Universitaet Leipzig, Leipzig

All Listed Sponsors

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

National Cancer Institute (NCI)

NIH

lead

Fred Hutchinson Cancer Center

OTHER