NCT00025038View on ClinicalTrials.gov

Combination Chemotherapy Followed By Donor Bone Marrow or Umbilical Cord Blood Transplant in Treating Children With Newly Diagnosed Juvenile Myelomonocytic Leukemia

PHASE2CompletedINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

June 30, 2001

Primary Completion Date

October 31, 2007

Conditions
Juvenile Myelomonocytic Leukemia
Interventions
DRUG

tipifarnib

Given orally

DRUG

isotretinoin

Given orally

DRUG

fludarabine phosphate

Given IV

DRUG

cytarabine

Given IV

RADIATION

radiation therapy

Undergo total body irradiation

DRUG

cyclophosphamide

Given IV

BIOLOGICAL

anti-thymocyte globulin

Given IV

PROCEDURE

allogeneic bone marrow transplantation

Undergo allogeneic bone marrow transplant

PROCEDURE

double-unit umbilical cord blood transplantation

PROCEDURE

umbilical cord blood transplantation

Undergo allogeneic cord blood transplant

OTHER

laboratory biomarker analysis

Correlative studies

Trial Locations (1)

91006-3776

Children's Oncology Group, Arcadia

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT00025038 - Combination Chemotherapy Followed By Donor Bone Marrow or Umbilical Cord Blood Transplant in Treating Children With Newly Diagnosed Juvenile Myelomonocytic Leukemia | Biotech Hunter | Biotech Hunter