8,053
Participants
Start Date
June 30, 2001
Primary Completion Date
October 31, 2010
Study Completion Date
September 30, 2013
RPT + INH once weekly for 3 months given by DOT
"Rifapentine (RPT) 900 mg once-weekly x 12 doses (3 months) for persons \> 50.0 kg. For persons \< 50.0 kg, the following doses will be given (Weight/Dose): 10.0-14.0 kg / 300 mg; 14.1-25.0 kg / 450 mg; 25.1-32.0 kg / 600 mg; 32.1-50.0 kg / 750 mg.~PLUS~Isoniazid (INH) 15 mg/kg (rounded up to nearest 50 or 100 mg; 900 mg max) once weekly x 12 doses if \> 12 years old. INH 25 mg/kg (round up to nearest 50 or 100 mg; 900 mg max) if 2-11 years old.~Therapy will be given by Directly Observed Therapy (DOT)."
Isoniazid (INH) daily for 9 months
Isoniazid (INH) 5 mg/kg (rounded up to nearest 50 or 100 mg; 300 mg max) daily x 270 doses (9 months) For children age 2 - 11, INH 10-15 mg/kg (round up to nearest 50 or 100 mg; 300 mg max) will be given.
Columbia University/Presbyterian Medical Center, New York
Harlem Hospital Center, New York
Washington, D.C. VAMC, Washington D.C.
Carolinas Medical Center, Charlotte
Emory University, Department of Medicine, Atlanta
Duke University Medical Center, Durham
Vanderbilt University Medical Center, Nashville
Hines VA Medical Center, Hines
Chicago VA Medical Center (Lakeside), Chicago
Central Arkansas Veterans Health System, Little Rock
Michael Debakey Veterans Affairs Medical Center, Houston
Audi L. Murphy VA Hospital, San Antonio
Denver Department of Public Health and Hospitals, Denver
LA County/USC Medical Center, Los Angeles
UCSD Medical Center, San Diego
University of California, San Francisco, San Francisco
Seattle King County Health Department, Seattle
Johns Hopkins University School of Medicine, Baltimore
Boston Medical Center, Boston
New Jersey Medical School, Newark
University of North Texas Health Science Center, Fort Worth
Universidade Federal do Rio de Janeiro, Rio de Janeiro
University of British Columbia, Vancouver
University of Manitoba, Winnipeg
Montreal Chest Institute McGill University, Montreal
Agencia de Salut Publica, Barcelona
US Department of Veterans Affairs
FED
Centers for Disease Control and Prevention
FED