R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas

PHASE2CompletedINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

July 17, 2001

Primary Completion Date

February 19, 2009

Study Completion Date

February 19, 2009

Conditions
Neurofibroma, PlexiformNeurofibromatosis Type I
Interventions
DRUG

tipifarnib

Given orally, 200 mg/m\^2/dose BSA every 12 hours by mouth (po) daily x 21 days, Course is every 28 days

OTHER

placebo

Patients receive oral placebo every 12 hours on days 1-21. Courses repeat as in arm I.

Trial Locations (12)

13210

SUNY Upstate Medical University, NY (M1303), Syracuse

19104

Childrens Hospital of Philadelphia, PA (M1257), Philadelphia

20892

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda

21231

Johns Hopkins Oncology Center (M1011), Baltimore

35233

University of Alabama at Birmingham (M1149), Birmingham

45229

Cincinnati Children's Hospital (FWA 00002988), Cincinnati

60614

Children's Memorial Hospital, Chicago, IL (M1484), Chicago

63110

St. Louis Children's Hospital, St. Louis, MO (M1123), St Louis

77030

Texas Children's Hospital, Houston, TX (M1060), Houston

90027

Children's Hospital Los Angeles, CA (M1118), Los Angeles

02115

The Children's Hospital, Dana-Farber Cancer Institute, Boston, MA (M1034), Boston

D-22419

Klinikum Nord, Hamburg, Germany (FWA 00003228), Hamburg

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT00021541 - R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas | Biotech Hunter | Biotech Hunter