Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

PHASE2RecruitingINTERVENTIONAL
Enrollment

2,530

Participants

Timeline

Start Date

October 2, 2001

Primary Completion Date

January 1, 2029

Study Completion Date

January 1, 2029

Conditions
Anxiety DisordersMajor Depressive Disorder
Interventions
BEHAVIORAL

Attention Bias Modification Training

The intervention is computer-based. The active and control treatments have two components. In one component of the active intervention, subjects are asked to indicate the identity of a letter that appears behind a neutral face, opposite from an angry face. In another component of the active intervention, subjects are asked to identify numbers that are hidden within a puzzle, in locations distal from angry faces. In both components of the active intervention, subjects implicitly learn to shift their attention away from angry faces. This is because the faces are systematically arranged to be far removed from letters and numbers that need to be identified. The control arm of the intervention involves similar components. However, unlike in the intervention arm, angry faces appear in various locations near letters and numbers. Therefore, attention is not shaped in the control arm. This intervention requires five minutes per session and is administered before weekly psychotherapy sessions.

DRUG

Fluoxetine

Randomized assignment.

Trial Locations (1)

20892

RECRUITING

National Institutes of Health Clinical Center, Bethesda

All Listed Sponsors
collaborator

University of Minnesota

OTHER

collaborator

University of Oregon

OTHER

collaborator

University of Maryland

OTHER

lead

National Institute of Mental Health (NIMH)

NIH