Combination Chemotherapy Followed by Surgery in Treating Patients With Localized Prostate Cancer

35 mg/m2 i.v. over 15 - 30 minutes will be administered immediately after the mitoxantrone on the same schedule.

Initial dose will be 2 mg/m2 weekly for 3 of every 4 weeks. The dose will then be escalated as described in the dose escalation section up to a maximum dose of 6 mg/m2 weekly for 3 of every 4 weeks.

Prostatectomy will be scheduled 2 - 4 weeks after the last dose of chemotherapy.