S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma

PHASE3CompletedINTERVENTIONAL
Enrollment

183

Participants

Timeline

Start Date

September 30, 2001

Primary Completion Date

May 31, 2006

Study Completion Date

November 30, 2012

Conditions
Malignant Neoplasms of Eye, Brain and Other Parts of Central Nervous System
Interventions
DRUG

carmustine

"40 mg/m\^2 IV over 1 hour on day 1 of each cycle 6 hours after O6-BG dose for experimental arm with O6=BG.~200 mg/m\^2 IV over 1 hour on day 2 of each cycle for the active comparator arm."

RADIATION

radiation therapy

5 days/week using one fraction per day and a dose of 180 cGy per fraction. Initial target volume is dose of 5040 cGy in 28 fractions with boost target volume of 1080 cGy in 6 fractions.

DRUG

O6-Benzylguanine

120 mg/m\^2 IV over 1 hour on day 1 of each cycle

Trial Locations (163)

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

24541

Danville Regional Medical Center, Danville

27534

Wayne Memorial Hospital, Incorporated, Goldsboro

28233

Presbyterian Cancer Center at Presbyterian Hospital, Charlotte

30033

Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur

30045

Gwinnett Medical Center, Lawrenceville

30060

Kennestone Cancer Center at Wellstar Kennestone Hospital, Marietta

30106

WellStar Cobb Hospital, Austell

30274

Southern Regional Medical Center, Riverdale

30309

Piedmont Hospital, Atlanta

30342

CCOP - Atlanta Regional, Atlanta

Northside Hospital Cancer Center, Atlanta

Saint Joseph's Hospital of Atlanta, Atlanta

30501

Northeast Georgia Medical Center, Gainesville

32514

West Florida Cancer Institute at West Florida Hospital - Pensacola, Pensacola

37660

Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport

39216

University of Mississippi Medical Center, Jackson

43015

Grady Memorial Hospital, Delaware

43055

Licking Memorial Cancer Care Program at Licking Memorial Hospital, Newark

43081

Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43214

Riverside Methodist Hospital Cancer Care, Columbus

43215

CCOP - Columbus, Columbus

Grant Riverside Cancer Services, Columbus

43222

Mount Carmel West Hospital, Columbus

43228

Doctors Hospital at Ohio Health, Columbus

43701

Genesis - Good Samaritan Hospital, Zanesville

44131

Community Oncology Group - Independence, Independence

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

44691

Cleveland Clinic - Wooster, Wooster

45044

Middletown Regional Hospital, Middletown

45373

UVMC Cancer Care Center at Upper Valley Medical Center, Troy

45385

Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital, Dayton

45409

David L. Rike Cancer Center at Miami Valley Hospital, Dayton

45415

Samaritan North Cancer Care Center, Dayton

45428

Veterans Affairs Medical Center - Dayton, Dayton

45429

CCOP - Dayton, Dayton

Charles F. Kettering Memorial Hospital, Kettering

45504

Mercy Medical Center Oncology Unit, Springfield

45505

Community Hospital of Springfield and Clark County, Springfield

45750

Strecker Cancer Center at Marietta Memorial Hospital, Marietta

46107

St. Francis Hospital and Health Centers, Beech Grove

48073

William Beaumont Hospital - Royal Oak Campus, Royal Oak

49017

Battle Creek Health System Cancer Care Center, Battle Creek

49307

Mecosta County General Hospital, Big Rapids

49423

Holland Community Hospital, Holland

49443

Hackley Hospital, Muskegon

49503

CCOP - Grand Rapids, Grand Rapids

Lacks Cancer Center at Saint Mary's Mercy Medical Center, Grand Rapids

Spectrum Health Cancer Care - Butterworth Campus, Grand Rapids

49506

Metropolitan Hospital, Grand Rapids

49684

Munson Medical Center, Traverse City

49770

Northern Michigan Hospital, Petoskey

52803

Genesis Regional Cancer Center at Genesis Medical Center, Davenport

52804

Genesis Medical Center - West Campus, Davenport

54601

Adena Regional Medical Center, Chillicothe

59101

CCOP - Montana Cancer Consortium, Billings

Deaconess Billings Clinic - Downtown, Billings

Hematology-Oncology Centers of the Northern Rockies - Billings, Billings

Northern Rockies Radiation Oncology Center, Billings

St. Vincent Healthcare, Billings

59107

Deaconess Billings Clinic Cancer Center, Billings

59301

Eastern Montana Cancer Center, Miles City

59405

Great Falls Clinic, Great Falls

Sletten Regional Cancer Institute, Great Falls

59601

St. Peter's Hospital, Helena

59701

St. James Community Hospital, Butte

59715

Bozeman Deaconess Hospital, Bozeman

Internal Medicine Associates of Bozeman, Bozeman

59801

Community Medical Center, Missoula

59802

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula

Montana Cancer Specialists at Montana Cancer Center, Missoula

59901

Glacier Oncology, PLLC, Kalispell

Kalispell Medical Oncology, Kalispell

60612

University of Illinois at Chicago Cancer Center, Chicago

Veterans Affairs Medical Center - Chicago Westside Hospital, Chicago

62002

Saint Anthony's Hospital at Saint Anthony's Health Center, Alton

62526

Decatur Memorial Hospital Cancer Care Institute, Decatur

62864

Good Samaritan Regional Health Center, Mount Vernon

63141

CCOP - St. Louis-Cape Girardeau, St Louis

David C. Pratt Cancer Center at St. John's Mercy, St Louis

63701

St. Francis Medical Center, Cape Girardeau

Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital, Gape Girardeau

64128

Veterans Affairs Medical Center - Kansas City, Kansas City

64131

CCOP - Kansas City, Kansas City

64804

Freeman Cancer Institute at Freeman Health System, Joplin

65804

St. John's Regional Health Center, Springfield

65807

Hulston Cancer Center at Cox Medical Center South, Springfield

66160

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City

66604

Stormont-Vail Cancer Center, Topeka

66606

St. Francis Comprehensive Cancer Center, Topeka

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas, P.A. - El Dorado, El Dorado

Cancer Center of Kansas - Salina, Salina

67068

Cancer Center of Kansas - Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Pratt Cancer Center of Kansas, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67203

Associates in Womens Health, Wichita

67208

Cancer Center of Kansas, P.A., Wichita

67214

Cancer Center of Kansas, P.A. - Wichita, Wichita

CCOP - Wichita, Wichita

Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita

Wesley Medical Center, Wichita

67357

Cancer Center of Kansas, P.A. - Parsons, Parsons

67401

Salina Regional Health Center, Salina

67801

Cancer Center of Kansas - Dodge City, Dodge City

67901

Southwest Medical Center, Liberal

68847

Good Samaritan Health Systems, Kearney

70112

MBCCOP - LSU Health Sciences Center, New Orleans

Medical Center of Louisiana - New Orleans, New Orleans

70806

Baton Rouge General Regional Cancer Center, Baton Rouge

70809

Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge

76508

CCOP - Scott and White Hospital, Temple

78234

Brooke Army Medical Center, Fort Sam Houston

78236

Wilford Hall Medical Center, Lackland Air Force Base

80030

St. Anthony North Hospital, Westminster

80033

Exempla Lutheran Medical Center, Wheat Ridge

80204

St. Anthony Central Hospital, Denver

80539

McKee Medical Center, Loveland

80631

North Colorado Medical Center, Greeley

80909

Memorial Hospital Cancer Center, Colorado Springs

82801

Welch Cancer Center, Sheridan

83404

Hematology Oncology Associates of Eastern Idaho, Idaho Falls

84112

Huntsman Cancer Institute at University of Utah, Salt Lake City

85006

Banner Good Samaritan Medical Center, Phoenix

CCOP - Western Regional, Arizona, Phoenix

85013

St. Joseph's Hospital and Medical Center, Phoenix

85306

Banner Thunderbird Medical Center, Phoenix

94533

North Bay Cancer Center, Fairfield

97030

Legacy Mount Hood Medical Center, Glesham

97062

Legacy Meridian Park Hospital, Tualatin

97210

Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center, Portland

97213

Providence Cancer Center at Providence Portland Medical Center, Portland

97222

Providence Milwaukie Hospital, Milwaukie

97225

CCOP - Columbia River Oncology Program, Portland

Providence St. Vincent Medical Center, Portland

97227

Institute of Oncology at Vilnius University, Portland

97309

Salem Hospital Regional Cancer Center, Salem

98003

St. Francis Hospital, Federal Way

98104

Fred Hutchinson Cancer Research Center, Seattle

Group Health Central Hospital, Seattle

Harborview Medical Center, Seattle

98114

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle

98195

University Cancer Center at University of Washington Medical Center, Seattle

98225

St. Joseph Hospital Community Cancer Center, Bellingham

98273

Skagit Valley Hospital Cancer Care Center, Mount Vernon

98284

North Puget Oncology at United General Hospital, Sedro-Woolley

98310

Olympic Hematology and Oncology, Bremerton

98405

Allenmore Hospital, Tacoma

CCOP - Northwest, Tacoma

98499

St. Clare Hospital, Tacoma

98507

Capital Medical Center, Olympia

98668

Southwest Washington Medical Center Cancer Center, Vancouver

98801

Central Washington Hospital, Wenatchee

Wenatchee Valley Clinic, Wenatchee

99202

Cancer Care Northwest - Spokane South, Spokane

99508

Alaska Regional Hospital Cancer Center, Anchorage

80217-3364

University of Colorado Cancer Center at University of Colorado Health Sciences Center, Denver

62781-0001

Regional Cancer Center at Memorial Medical Center, Springfield

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

SWOG Cancer Research Network

NETWORK

NCT00017147 - S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma | Biotech Hunter | Biotech Hunter