Biomarker (p53 Gene) Analysis and Combination Chemotherapy Followed by Radiation Therapy and Surgery in Treating Women With Large Operable or Locally Advanced or Inflammatory Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

1,856

Participants

Timeline

Start Date

March 31, 2001

Primary Completion Date

November 30, 2006

Conditions
Breast Cancer
Interventions
BIOLOGICAL

filgrastim

DRUG

cyclophosphamide

DRUG

docetaxel

DRUG

epirubicin hydrochloride

DRUG

fluorouracil

GENETIC

microarray analysis

OTHER

immunohistochemistry staining method

OTHER

laboratory biomarker analysis

PROCEDURE

biopsy

PROCEDURE

conventional surgery

PROCEDURE

neoadjuvant therapy

RADIATION

radiation therapy

Trial Locations (39)

1000

Institut Jules Bordet, Brussels

2610

Algemeen Ziekenhuis Sint-Augustinus, Wilrijk

3049

Hospitais da Universidade de Coimbra (HUC), Coimbra

5001

Kantonspital Aarau, Aarau

21079

Centre de Lutte Contre le Cancer Georges-Francois Leclerc, Dijon

33076

Institut Bergonie, Bordeaux

34298

Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle, Montpellier

44805

Centre Regional Rene Gauducheau, Nantes-Saint Herblain

49036

Centre Paul Papin, Angers

54511

Centre Alexis Vautrin, Vandœuvre-lès-Nancy

67085

Centre Paul Strauss, Strasbourg

70185

Orebro University Hospital, Örebro

76038

Centre Henri Becquerel, Rouen

92211

Centre Rene Huguenin, Saint-Cloud

B-4000

CHU Liege - Domaine Universitaire du Sart Tilman, Liège

F-85025

Centre Hospitalier Departemental, La Roche-sur-Yon

1091 HA

Onze Lieve Vrouwe Gasthuis, Amsterdam

2300 CA

Leiden University Medical Center, Leiden

3008 AE

Daniel Den Hoed Cancer Center at Erasmus Medical Center, Rotterdam

80-211

Medical University of Gdansk, Gdansk

02-781

Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw

1099-023 Codex

Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, S.A., Lisbon

Sl-1000

Institute of Oncology - Ljubljana, Ljubljana

S-413 45

Sahlgrenska University Hospital at Gothenburg University, Gothenburg (Goteborg)

S-22185

Lund University Hospital, Lund

S-20502

Malmo University Hospital, Malmo

S-43180

Sahlgrenska University Hospital - Molndal at Gothenburg University, Mölndal

S-171 76

Karolinska University Hospital - Huddinge, Stockholm

S-75185

Uppsala University Hospital, Uppsala

CH-3008

Swiss Institute for Applied Cancer Research, Bern

CH-3010

Inselspital Bern, Bern

CH-1211

Hopital Cantonal Universitaire de Geneve, Geneva

CH-1011

Centre Hospitalier Universitaire Vaudois, Lausanne

CH-8091

UniversitaetsSpital Zuerich, Zurich

NE4 6BE

Northern Centre for Cancer Treatment at Newcastle General Hospital, Newcastle upon Tyne

SO14 0YG

Royal South Hants Hospital, Southampton

DD1 9SY

Ninewells Hospital and Medical School, Dundee

EH4 2XU

Edinburgh Cancer Centre at Western General Hospital, Edinburgh

EH5 3SQ

Scottish Cancer Therapy Network, Edinburgh

All Listed Sponsors
collaborator

Swedish Breast Cancer Group

OTHER

collaborator

Swiss Cancer Institute

OTHER

collaborator

Anglo Celtic Cooperative Oncology Group

OTHER

lead

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

NCT00017095 - Biomarker (p53 Gene) Analysis and Combination Chemotherapy Followed by Radiation Therapy and Surgery in Treating Women With Large Operable or Locally Advanced or Inflammatory Breast Cancer | Biotech Hunter | Biotech Hunter