NCT00016302 - Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | Biotech Hunter

Enrollment

100

Participants

Timeline

Start Date

April 30, 2001

Primary Completion Date

July 31, 2007

Conditions

T-cell Childhood Acute Lymphoblastic LeukemiaUntreated Childhood Acute Lymphoblastic Leukemia

Interventions

DRUG

prednisone

Given orally

DRUG

vincristine sulfate

Given IV

DRUG

daunorubicin hydrochloride

Given IV

DRUG

asparaginase

Given IM

DRUG

methotrexate

Given IT and orally

DRUG

cyclophosphamide

Given IV

DRUG

cytarabine

Given IV or SC

DRUG

mercaptopurine

Given orally

DRUG

leucovorin calcium

Given IV or orally

DRUG

dexamethasone

Given orally

DRUG

doxorubicin hydrochloride

Given IV

DRUG

thioguanine

Given orally

RADIATION

radiation therapy

Undergo cranial irradiation

DRUG

nelarabine

Given IV

DRUG

pegaspargase

Given IM

RADIATION

radiation therapy

Undergo craniocervical radiotherapy

OTHER

pharmacological study

Correlative studies

OTHER

laboratory biomarker analysis

Correlative studies

Trial Locations (1)

91006-3776

Children's Oncology Group, Arcadia

All Listed Sponsors

lead

National Cancer Institute (NCI)

NIH