Gemcitabine Alone or in Combination With Other Chemotherapy Drugs in Treating Patients With Metastatic Cancer of the Pancreas

PHASE2CompletedINTERVENTIONAL
Enrollment

259

Participants

Timeline

Start Date

January 31, 2001

Primary Completion Date

June 30, 2004

Study Completion Date

April 30, 2009

Conditions
Pancreatic Cancer
Interventions
DRUG

cisplatin

50 mg/sq m IV infusion over 30 min on Days 1 \& 15 of ea cycle

DRUG

docetaxel

40 mg/sq m IV infusion over 60 min on Days 1 \& 8 of ea treatment cycle

DRUG

gemcitabine hydrochloride

"Gemcitabine only arm: 1500 mg/sq m in 250 mL NS IV infusion over 150 min Days 1, 8, \& 15 of ea cycle~* cisplastin arm: 1000 mg/sq m 250 mL NS IV infusion over 30 min Days 1, 8, 15 of ea cycle~* docetaxel and + irinotecan arms: 1000 mg/sq m in 250 mL NS IV infusion over 30 min Days 1 \& 8 of ea cycle"

DRUG

irinotecan hydrochloride

100 mg/q m in 500 mL D5W or D5NS IV infusion over 90 min Days 1 \& 8 of ea cycle

Trial Locations (76)

10021

Memorial Sloan-Kettering Cancer Center, New York

New York Weill Cornell Cancer Center at Cornell University, New York

10029

Mount Sinai Medical Center, NY, New York

11030

CCOP - North Shore University Hospital, Manhasset

North Shore University Hospital, Manhasset

11373

Elmhurst Hospital Center, Elmhurst

11432

Queens Cancer Center of Queens Hospital, Jamaica

13210

State University of New York - Upstate Medical University, Syracuse

Veterans Affairs Medical Center - Syracuse, Syracuse

13217

CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse

14215

Veterans Affairs Medical Center - Buffalo, Buffalo

19713

CCOP - Christiana Care Health Services, Newark

20007

Lombardi Cancer Center, Washington D.C.

20422

Veterans Affairs Medical Center - Washington, DC, Washington D.C.

21201

Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore

Veterans Affairs Medical Center - Baltimore, Baltimore

22902

Martha Jefferson Hospital, Charlottesville

23502

Virginia Oncology Associates - Norfolk, Norfolk

24014

Oncology and Hematology Associates of Southwest Virginia, Inc., Roanoke

25701

St. Mary's Medical Center, Huntington

27705

Veterans Affairs Medical Center - Durham, Durham

27710

Duke Comprehensive Cancer Center, Durham

28025

NorthEast Oncology Associates, Concord

28374

FirstHealth Moore Regional Hospital, Pinehurst

28805

Veterans Affairs Medical Center - Asheville, Asheville

32804

Florida Hospital Cancer Institute, Orlando

33021

Memorial Regional Hospital Comprehensive Cancer Center, Hollywood

33140

CCOP - Mount Sinai Medical Center, Miami Beach

33316

Broward General Medical Center, Fort Lauderdale

33401

Helen and Harry Gray Cancer Institute at Good Samaritan Medical Center, West Palm Beach

36207

Northeast Alabama Regional Medical Center, Anniston

40207

Baptist Hospital East - Louisville, Louisville

46601

CCOP - Northern Indiana CR Consortium, South Bend

49085

Lakeland Medical Center - St. Joseph, Saint Joseph

52722

Hematology Oncology Associates of the Quad Cities, Bettendorf

54501

Ministry Medical Group - Northern Region, Rhinelander

55417

Veterans Affairs Medical Center - Minneapolis, Minneapolis

55455

University of Minnesota Cancer Center, Minneapolis

58102

Veterans Affairs Medical Center - Fargo, Fargo

60305

West Suburban Center for Cancer Care, River Forest

60612

Veterans Affairs Medical Center - Chicago (Westside Hospital), Chicago

60640

Louis A. Weiss Memorial Hospital, Chicago

61108

Saint Anthony Medical Center, Rockford

63110

Barnes-Jewish Hospital, St Louis

65201

Veterans Affairs Medical Center - Columbia (Truman Memorial), Columbia

65203

Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia

75216

Veterans Affairs Medical Center - Dallas, Dallas

89106

CCOP - Southern Nevada Cancer Research Foundation, Las Vegas

Veterans Affairs Medical Center - Las Vegas, Las Vegas

92161

Veterans Affairs Medical Center - San Diego, San Diego

94115

UCSF Comprehensive Cancer Center, San Francisco

94121

Veterans Affairs Medical Center - San Francisco, San Francisco

92093-0658

Rebecca and John Moores UCSD Cancer Center, La Jolla

20307-5000

Walter Reed Army Medical Center, Washington D.C.

60637-1470

University of Chicago Cancer Research Center, Chicago

46885-5099

Fort Wayne Medical Oncology and Hematology, Incorporated, Fort Wayne

52242-1009

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

02115

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

01655

University of Massachusetts Memorial Medical Center - University Campus, Worcester

68198-7680

University of Nebraska Medical Center, Omaha

03756-0002

Norris Cotton Cancer Center, Lebanon

08103

Cooper University Hospital, Camden

14263-0001

Roswell Park Cancer Institute, Buffalo

27599-7295

Lineberger Comprehensive Cancer Center, UNC, Chapel Hill

28302-2000

Cape Fear Valley Health System, Fayetteville

28503-1678

Lenoir Memorial Hospital Cancer Center, Kinston

28402-9025

New Hanover Regional Medical Center, Wilmington

27104-4241

CCOP - Southeast Cancer Control Consortium, Winston-Salem

27157-1082

Comprehensive Cancer Center at Wake Forest University, Winston-Salem

43210-1240

Arthur G. James Cancer Hospital - Ohio State University, Columbus

02906

Lifespan: The Miriam Hospital, Providence

05201

Green Mountain Oncology Group, Bennington

05401-3498

Vermont Cancer Center at University of Vermont, Burlington

05009

Veterans Affairs Medical Center - White River Junction, White River Junction

23298-0037

MBCCOP - Massey Cancer Center, Richmond

00936-5067

University of Puerto Rico School of Medicine Medical Sciences Campus, San Juan

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER

NCT00012220 - Gemcitabine Alone or in Combination With Other Chemotherapy Drugs in Treating Patients With Metastatic Cancer of the Pancreas | Biotech Hunter | Biotech Hunter