NCT00008450View on ClinicalTrials.gov

Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant

PHASE1CompletedINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

August 11, 1997

Primary Completion Date

October 25, 2011

Study Completion Date

December 26, 2018

Conditions
Adenosine Deaminase DeficiencyAutosomal Recessive DisorderImmune System DisorderPurine-Nucleoside Phosphorylase DeficiencySevere Combined ImmunodeficiencySevere Combined Immunodeficiency With Absence of T and B CellsX-Linked Severe Combined Immunodeficiency
Interventions
PROCEDURE

Allogeneic Bone Marrow Transplantation

Undergo allogeneic bone marrow transplant

DRUG

Cyclosporine

Given PO or IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Mycophenolate Mofetil

Given PO or IV

PROCEDURE

Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation

Undergo nonmyeloablative allogeneic hematopoietic stem cell transplant

RADIATION

Total-Body Irradiation

Undergo TBI

Trial Locations (1)

98109

Fred Hutch/University of Washington Cancer Consortium, Seattle

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Fred Hutchinson Cancer Center

OTHER

NCT00008450 - Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant | Biotech Hunter | Biotech Hunter