Adjuvant Stage 2-3A Breast Cancer With Positive Lymph Nodes

Neupogen (G-CSF) given at a dose of 10 ugm/kg subcutaneously starting on day 5 and continuing until ANC \> 10,000/uL x1 day after the nadir cycles 1-3.

cyclophosphamide 700 mg/m2 daily for 3 day every 3 weeks cycles 1-3

Patients then receive doxorubicin IV on day 1.

Paclitaxel 160 mg/m2 given over 72 hours by continuous infusion days 1-3

tamoxifen at a dose of 20 mg daily for 5 years after chemotherapy is completed

Patients receive paclitaxel IV continuously and cyclophosphamide IV over 2 hours on days 1-3. Patients also receive filgrastim (G-CSF) subcutaneously (SC) beginning on day 5 and continuing until day 14 or until blood counts recover. Treatment repeats every 21 days for 3 courses. Patients then receive doxorubicin IV on day 1 and G-CSF SC on days 2-11 every 21 days for 4 courses.

Beginning 3-6 weeks after the completion of chemotherapy, patients receive radiotherapy 5 days a week for 6-7 weeks.