Antibody and Delayed Cyclosporine Versus Initial Cyclosporine Alone in Patients Receiving Kidney Transplants

NACompletedINTERVENTIONAL
Enrollment

350

Participants

Timeline

Start Date

April 30, 2000

Study Completion Date

March 31, 2004

Conditions
Kidney TransplantationChronic Allograft Nephropathy
Interventions
BIOLOGICAL

Cyclosporine

BIOLOGICAL

Anti-human thymocyte globulin (rabbit)

Anti-human thymocyte globulin (rabbit) will be given at a dose of 1.5 mg/kg while undergoing transplantation. Second and subsequent doses of Thymoglobulin® will be administered if, at 24 hours post-anastomosis, the serum creatinine has not decreased by at least 20% from the pre-transplant level. Additional Anti-human thymocyte globulin (rabbit) will be given at a dose of 1.5mg/kg daily for a minimum of 5 days to a maximum of 7 days.

DRUG

Tacrolimus

Trial Locations (1)

20850

Ilene Blechman-Krom, Rockville

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT00007787 - Antibody and Delayed Cyclosporine Versus Initial Cyclosporine Alone in Patients Receiving Kidney Transplants | Biotech Hunter | Biotech Hunter