Comparing the Effects of Amiodarone, Sotalol, and Placebo in Maintaining Sinus Rhythm in Patients With Atrial Fibrillation Converted to Sinus Rhythm

PHASE3CompletedINTERVENTIONAL
Enrollment

706

Participants

Timeline

Start Date

April 30, 1998

Primary Completion Date

October 31, 2002

Study Completion Date

December 31, 2003

Conditions
Atrial FibrillationCerebrovascular AccidentDeath, Sudden
Interventions
DRUG

Amiodarone

Patients assigned will receive 400 mg bid for 14 days, 400 mg QAM and 200 mg QHS for 14 days, 300 mg qd for 48 weeks, then 200 mg qd.

DRUG

Sotalol

Patients assigned will receive 80 mg bid for 7 days and 160 mg bid thereafter.

Trial Locations (28)

15240

VA Pittsburgh Health Care System, Pittsburgh

20422

VA Medical Center, DC, Washington D.C.

23249

Hunter Holmes McGuire VA Medical Center, Richmond

30904

VA Medical Center, Augusta, Augusta

33612

James A. Haley Veterans Hospital, Tampa, Tampa

33708

VA Medical Center, Bay Pines, Bay Pines

38104

VA Medical Center, Memphis, Memphis

53705

Wlliam S. Middleton Memorial Veterans Hospital, Madison, Madison

55417

VA Medical Center, Minneapolis, Minneapolis

58102

VA Medical Center, Fargo, Fargo

63106

VA Medical Center, St Louis, St Louis

64128

VA Medical Center, Kansas City MO, Kansas City

75216

VA North Texas Health Care System, Dallas, Dallas

85723

Southern Arizona VA Health Care System, Tucson, Tucson

90073

VA Greater Los Angeles Healthcare System, West LA, West Los Angeles

91343

VA Greater Los Angeles HCS, Sepulveda, Sepulveda

92357

VA Medical Center, Loma Linda, Loma Linda

93703

VA Central California Health Care System, Fresno, Fresno

97201

VA Medical Center, Portland, Portland

72114-1706

Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock, No. Little Rock

94304-1290

VA Palo Alto Health Care System, Palo Alto

06516

VA Connecticut Health Care System (West Haven), West Haven

60141-5000

Edward Hines, Jr. VA Hospital, Hines

52246-2208

VA Medical Center, Iowa City, Iowa City

02301

VA Boston Healthcare System, Brockton Campus, Brockton

87108-5153

New Mexico VA Health Care System, Albuquerque, Albuquerque

02908

VA Medical Center, Providence, Providence

37212-2637

VA Medical Center, Nashville

All Listed Sponsors
lead

US Department of Veterans Affairs

FED

NCT00007605 - Comparing the Effects of Amiodarone, Sotalol, and Placebo in Maintaining Sinus Rhythm in Patients With Atrial Fibrillation Converted to Sinus Rhythm | Biotech Hunter | Biotech Hunter