Fludarabine and Cyclophosphamide Followed by Peripheral Stem Cell Transplant in Treating Patients With Leukemia or Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

February 28, 2001

Primary Completion Date

January 31, 2007

Study Completion Date

October 31, 2011

Conditions
LeukemiaLymphoma
Interventions
DRUG

fludarabine phosphate

30 mg/sq m/day IV infusion for 5 days (Days -7 thru -3)

DRUG

Cyclophosphamide

1 g/sq m/day IV infusion x 3 days (Days -5 thru -3)

BIOLOGICAL

PBSC

2-8,000,000/kg CD34+ cells via infusion on Day 0

DRUG

G-CSF

5 ug/kg/day subQ injection until ANC \> 1000/uL for 3 days beginning Day 5

BIOLOGICAL

Donor lymphocytes

10,000,000 CD3+ cells/kg via infusion

Trial Locations (19)

10029

Mount Sinai Medical Center, New York

11373

Elmhurst Hospital Center, Elmhurst

11432

Queens Cancer Center of Queens Hospital, Jamaica

19713

CCOP - Christiana Care Health Services, Newark

19805

St. Francis Hospital, Wilmington

19958

Beebe Medical Center, Lewes

21921

Union Hospital Cancer Center at Union Hospital, Elkton MD

52242

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

92161

Veterans Affairs Medical Center - San Diego, San Diego

94115

UCSF Comprehensive Cancer Center, San Francisco

92093-0658

Rebecca and John Moores UCSD Cancer Center, La Jolla

01655

UMASS Memorial Cancer Center - University Campus, Worcester

08043

Cancer Institute of New Jersey at the Cooper University Hospital - Voorhees, Voorhees Township

14263-0001

Roswell Park Cancer Institute, Buffalo

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

27157-1096

Wake Forest University Comprehensive Cancer Center, Winston-Salem

43210-1240

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University, Columbus

15224-1791

Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital, Pittsburgh

23298-0037

Massey Cancer Center at Virginia Commonwealth University, Richmond

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Cancer and Leukemia Group B

NETWORK

NCT00006252 - Fludarabine and Cyclophosphamide Followed by Peripheral Stem Cell Transplant in Treating Patients With Leukemia or Lymphoma | Biotech Hunter | Biotech Hunter