Multimodality Treatment for Women With Stage II, Stage III, or Stage IV Breast Cancer

infusion 4 mg/kg load week 1; 2 mg/kg weekly thereafter for 12 weeks

600 mg/m2, intravenous infusion every 3 weeks for four cycles

60 mg/m2 intravenously, 5-10 minutes, every 3 weeks, up to 12 weeks

90 mg/m2 weekly, intravenously 1 hour after herceptin, given weekly up to 12 weeks or 175 mg/m2, intravenously every 3 weeks, up to 12 weeks (only if not receiving Herceptin®)

Surgical excision will take place 12-13 weeks for the neo-adjuvant herceptin setting and 12-13 weeks in the non-herceptin setting. Surgery will take place prior to chemotherapy in the adjuvant herceptin setting