Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia

PHASE3CompletedINTERVENTIONAL
Enrollment

3,054

Participants

Timeline

Start Date

June 30, 2000

Primary Completion Date

November 30, 2007

Study Completion Date

June 30, 2008

Conditions
Leukemia
Interventions
DRUG

cyclophosphamide

Given IV

DRUG

cytarabine

Given IT

DRUG

daunorubicin hydrochloride

Given IV

DRUG

dexamethasone

Given PO

DRUG

doxorubicin hydrochloride

Dose 25 g/m² IV Days 0, 7, 14, given over a period of 15 minutes to 2 hours

DRUG

mercaptopurine

Given PO

DRUG

methotrexate

Given PO and IT

DRUG

pegaspargase

Given IM

DRUG

thioguanine

Given PO

DRUG

vincristine sulfate

Given IV

RADIATION

radiation therapy

Undergo radiation therapy

Trial Locations (130)

2031

Sydney Children's Hospital, Randwick

4029

Royal Children's Hospital, Brisbane

6001

Princess Margaret Hospital for Children, Perth

10021

Memorial Sloan-Kettering Cancer Center, New York

New York Weill Cornell Cancer Center at Cornell University, New York

10032

Herbert Irving Comprehensive Cancer Center at Columbia University, New York

10461

Albert Einstein Cancer Center at Albert Einstein College of Medicine, The Bronx

10595

New York Medical College, Valhalla

11042

Schneider Children's Hospital, New Hyde Park

11203

SUNY Downstate Medical Center, Brooklyn

11212

Brookdale University Hospital and Medical Center, Brooklyn

11219

Comprehensive Cancer Center at Maimonides Medical Center, Brooklyn

11794

Long Island Cancer Center at Stony Brook University Hospital, Stony Brook

12208

Cancer Center of Albany Medical Center, Albany

13210

SUNY Upstate Medical University Hospital, Syracuse

15213

Children's Hospital of Pittsburgh, Pittsburgh

17033

Children's Hospital at Milton S. Hershey Medical Center, Hershey

19104

Children's Hospital of Philadelphia, Philadelphia

19899

Alfred I. duPont Hospital for Children, Wilmington

20007

Lombardi Cancer Center at Georgetown University Medical Center, Washington D.C.

21215

Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore

23507

Children's Hospital of the King's Daughters, Norfolk

25302

West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division, Charleston

25701

Cabell Huntington Hospital, Huntington

27599

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

28233

Presbyterian Cancer Center at Presbyterian Hospital, Charlotte

30342

AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus, Atlanta

31201

Medical Center of Central Georgia, Macon

31405

Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah

37901

East Tennessee Children's Hospital, Knoxville

43601

Toledo Children's Hospital, Toledo

43608

St. Vincent Mercy Medical Center, Toledo

45404

Children's Medical Center - Dayton, Dayton

48202

Josephine Ford Cancer Center at Henry Ford Health System, Detroit

48910

Breslin Cancer Center at Ingham Regional Medical Center, Lansing

49503

DeVos Children's Hospital, Grand Rapids

50308

Blank Children's Hospital, Des Moines

54301

Bellin Memorial Hospital, Green Bay

54449

CCOP - Marshfield Clinic Research Foundation, Marshfield

54601

Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse

55404

Children's Hospitals and Clinics - Minneapolis/St. Paul, Minneapolis

55455

University of Minnesota Cancer Center, Minneapolis

55805

St. Mary's - Duluth Clinic Cancer Center, Duluth

55905

Mayo Clinic Cancer Center, Rochester

58122

Meritcare Roger Maris Cancer Center, Fargo

60601

University of Chicago Cancer Research Center, Chicago

60612

University of Illinois Medical Center, Chicago

64108

Children's Mercy Hospital, Kansas City

68114

Children's Hospital of Omaha, Omaha

70112

MBCCOP - LSU Health Sciences Center, New Orleans

75230

Medical City Dallas Hospital, Dallas

76508

CCOP - Scott and White Hospital, Temple

78701

Children's Hospital of Austin, Austin

79106

Texas Tech University Health Sciences Center School of Medicine, Amarillo

79410

Covenant Children's Hospital, Lubbock

80218

Children's Hospital Cancer Center, Denver

Presbyterian - St. Luke's Medical Center, Denver

83712

Mountain States Tumor Institute - Boise, Boise

85016

Phoenix Children's Hospital, Phoenix

89109

Sunrise Hospital and Medical Center, Las Vegas

90048

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles

90242

Southern California Permanente Medical Group, Downey

92120

Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego

92354

Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda

92868

Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center, Orange

Children's Hospital of Orange County, Orange

93102

Santa Barbara Cottage Hospital, Santa Barbara

94143

UCSF Comprehensive Cancer Center, San Francisco

94535

General Robert Huyser Cancer Center at David Grant Medical Center, Travis Air Force Base

95825

Kaiser Permanente Medical Center - Sacramento, Sacramento

97225

CCOP - Columbia River Oncology Program, Portland

98105

Children's Hospital and Regional Medical Center - Seattle, Seattle

98112

Group Health Central Hospital, Seattle

91010-3000

City of Hope Comprehensive Cancer Center, Duarte

90027-0700

Children's Hospital Los Angeles, Los Angeles

90095-1781

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles

93638-8762

Children's Hospital Central California, Madera

94609-1809

Children's Hospital and Research Center at Oakland, Oakland

95051-5386

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

06360-7106

Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington

06520-8064

Yale Comprehensive Cancer Center, New Haven

20010-2970

Children's National Medical Center, Washington D.C.

60068-1174

Lutheran General Cancer Care Center, Park Ridge

62794-9658

Southern Illinois University School of Medicine, Springfield

46202-5225

Riley Children Cancer Center at Riley Hospital for Children, Indianapolis

52242-1009

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

40536-0284

Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington

40202-3830

Kosair Children's Hospital, Louisville

01107

Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield

48109-0914

University of Michigan Comprehensive Cancer Center, Ann Arbor

49007-5364

Bronson Methodist Hospital, Kalamazoo

48073-6769

CCOP - Beaumont, Royal Oak

William Beaumont Hospital - Royal Oak, Royal Oak

68198-2168

UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha

07039

St. Barnabas Medical Center, Livingston

08903

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick

07112-2094

Newark Beth Israel Medical Center, Newark

07503

St. Joseph's Hospital and Medical Center, Paterson

07901

Valerie Fund Children's Center at Atlantic Health, Summit

11201-5493

Brooklyn Hospital Center, Brooklyn

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

58103-4940

Dakota Cancer Institute at Innovis Health - Dakota Clinic, Fargo

44308-1062

Children's Hospital Medical Center of Akron, Akron

45229-3039

Cincinnati Children's Hospital Medical Center, Cincinnati

44106-5065

Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland

43205-2696

Columbus Children's Hospital, Columbus

97239-3098

Doernbecher Children's Hospital at Oregon Health & Science University, Portland

17822-1320

Geisinger Medical Center, Danville

02903

Rhode Island Hospital, Providence

57117-5039

Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls

37614-0622

East Tennessee State University Cancer Center at Johnson City Medical Center, Johnson City

37232-6310

Vanderbilt Children's Hospital, Nashville

77030-4009

MD Anderson Cancer Center at University of Texas, Houston

78229-3900

MBCCOP - South Texas Pediatrics, San Antonio

78229-3902

Methodist Cancer Center at Methodist Specialty and Transplant Hospital, San Antonio

99210-0248

Deaconess Medical Center, Spokane

98415-0299

Mary Bridge Children's Hospital and Health Center, Tacoma

53792-6164

University of Wisconsin Comprehensive Cancer Center, Madison

54449-5772

Marshfield Clinic - Marshfield Center, Marshfield

V6H 3V4

British Columbia Children's Hospital, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

A1B 3V6

Janeway Children's Health and Rehabilitation Centre, St. John's

B3J 3G9

IWK Health Centre, Halifax

N6C 2V5

Children's Hospital of Western Ontario, London

S4T 7T1

Allan Blair Cancer Centre at Pasqua Hospital, Regina

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

Unknown

Starship Children's Health, Auckland

CH 3010

Swiss Pediatric Oncology Group Bern, Bern

CH 1211

Swiss Pediatric Oncology Group Geneva, Geneva

CH 1011

Swiss Pediatric Oncology Group Lausanne, Lausanne

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00005945 - Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia | Biotech Hunter | Biotech Hunter