3,054
Participants
Start Date
June 30, 2000
Primary Completion Date
November 30, 2007
Study Completion Date
June 30, 2008
cyclophosphamide
Given IV
cytarabine
Given IT
daunorubicin hydrochloride
Given IV
dexamethasone
Given PO
doxorubicin hydrochloride
Dose 25 g/m² IV Days 0, 7, 14, given over a period of 15 minutes to 2 hours
mercaptopurine
Given PO
methotrexate
Given PO and IT
pegaspargase
Given IM
thioguanine
Given PO
vincristine sulfate
Given IV
radiation therapy
Undergo radiation therapy
Sydney Children's Hospital, Randwick
Royal Children's Hospital, Brisbane
Princess Margaret Hospital for Children, Perth
Memorial Sloan-Kettering Cancer Center, New York
New York Weill Cornell Cancer Center at Cornell University, New York
Herbert Irving Comprehensive Cancer Center at Columbia University, New York
Albert Einstein Cancer Center at Albert Einstein College of Medicine, The Bronx
New York Medical College, Valhalla
Schneider Children's Hospital, New Hyde Park
SUNY Downstate Medical Center, Brooklyn
Brookdale University Hospital and Medical Center, Brooklyn
Comprehensive Cancer Center at Maimonides Medical Center, Brooklyn
Long Island Cancer Center at Stony Brook University Hospital, Stony Brook
Cancer Center of Albany Medical Center, Albany
SUNY Upstate Medical University Hospital, Syracuse
Children's Hospital of Pittsburgh, Pittsburgh
Children's Hospital at Milton S. Hershey Medical Center, Hershey
Children's Hospital of Philadelphia, Philadelphia
Alfred I. duPont Hospital for Children, Wilmington
Lombardi Cancer Center at Georgetown University Medical Center, Washington D.C.
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore
Children's Hospital of the King's Daughters, Norfolk
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division, Charleston
Cabell Huntington Hospital, Huntington
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus, Atlanta
Medical Center of Central Georgia, Macon
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah
East Tennessee Children's Hospital, Knoxville
Toledo Children's Hospital, Toledo
St. Vincent Mercy Medical Center, Toledo
Children's Medical Center - Dayton, Dayton
Josephine Ford Cancer Center at Henry Ford Health System, Detroit
Breslin Cancer Center at Ingham Regional Medical Center, Lansing
DeVos Children's Hospital, Grand Rapids
Blank Children's Hospital, Des Moines
Bellin Memorial Hospital, Green Bay
CCOP - Marshfield Clinic Research Foundation, Marshfield
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse
Children's Hospitals and Clinics - Minneapolis/St. Paul, Minneapolis
University of Minnesota Cancer Center, Minneapolis
St. Mary's - Duluth Clinic Cancer Center, Duluth
Mayo Clinic Cancer Center, Rochester
Meritcare Roger Maris Cancer Center, Fargo
University of Chicago Cancer Research Center, Chicago
University of Illinois Medical Center, Chicago
Children's Mercy Hospital, Kansas City
Children's Hospital of Omaha, Omaha
MBCCOP - LSU Health Sciences Center, New Orleans
Medical City Dallas Hospital, Dallas
CCOP - Scott and White Hospital, Temple
Children's Hospital of Austin, Austin
Texas Tech University Health Sciences Center School of Medicine, Amarillo
Covenant Children's Hospital, Lubbock
Children's Hospital Cancer Center, Denver
Presbyterian - St. Luke's Medical Center, Denver
Mountain States Tumor Institute - Boise, Boise
Phoenix Children's Hospital, Phoenix
Sunrise Hospital and Medical Center, Las Vegas
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles
Southern California Permanente Medical Group, Downey
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center, Orange
Children's Hospital of Orange County, Orange
Santa Barbara Cottage Hospital, Santa Barbara
UCSF Comprehensive Cancer Center, San Francisco
General Robert Huyser Cancer Center at David Grant Medical Center, Travis Air Force Base
Kaiser Permanente Medical Center - Sacramento, Sacramento
CCOP - Columbia River Oncology Program, Portland
Children's Hospital and Regional Medical Center - Seattle, Seattle
Group Health Central Hospital, Seattle
City of Hope Comprehensive Cancer Center, Duarte
Children's Hospital Los Angeles, Los Angeles
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles
Children's Hospital Central California, Madera
Children's Hospital and Research Center at Oakland, Oakland
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington
Yale Comprehensive Cancer Center, New Haven
Children's National Medical Center, Washington D.C.
Lutheran General Cancer Care Center, Park Ridge
Southern Illinois University School of Medicine, Springfield
Riley Children Cancer Center at Riley Hospital for Children, Indianapolis
Holden Comprehensive Cancer Center at University of Iowa, Iowa City
Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington
Kosair Children's Hospital, Louisville
Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield
University of Michigan Comprehensive Cancer Center, Ann Arbor
Bronson Methodist Hospital, Kalamazoo
CCOP - Beaumont, Royal Oak
William Beaumont Hospital - Royal Oak, Royal Oak
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha
St. Barnabas Medical Center, Livingston
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick
Newark Beth Israel Medical Center, Newark
St. Joseph's Hospital and Medical Center, Paterson
Valerie Fund Children's Center at Atlantic Health, Summit
Brooklyn Hospital Center, Brooklyn
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Dakota Cancer Institute at Innovis Health - Dakota Clinic, Fargo
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland
Columbus Children's Hospital, Columbus
Doernbecher Children's Hospital at Oregon Health & Science University, Portland
Geisinger Medical Center, Danville
Rhode Island Hospital, Providence
Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls
East Tennessee State University Cancer Center at Johnson City Medical Center, Johnson City
Vanderbilt Children's Hospital, Nashville
MD Anderson Cancer Center at University of Texas, Houston
MBCCOP - South Texas Pediatrics, San Antonio
Methodist Cancer Center at Methodist Specialty and Transplant Hospital, San Antonio
Deaconess Medical Center, Spokane
Mary Bridge Children's Hospital and Health Center, Tacoma
University of Wisconsin Comprehensive Cancer Center, Madison
Marshfield Clinic - Marshfield Center, Marshfield
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Children's Health and Rehabilitation Centre, St. John's
IWK Health Centre, Halifax
Children's Hospital of Western Ontario, London
Allan Blair Cancer Centre at Pasqua Hospital, Regina
Saskatoon Cancer Centre, Saskatoon
Starship Children's Health, Auckland
Swiss Pediatric Oncology Group Bern, Bern
Swiss Pediatric Oncology Group Geneva, Geneva
Swiss Pediatric Oncology Group Lausanne, Lausanne
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK