NCT00005803 - Autologous Stem Cell Transplant Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoma | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

September 30, 1999

Primary Completion Date

January 31, 2016

Study Completion Date

October 31, 2018

Conditions

Prolymphocytic LeukemiaRecurrent Adult Hodgkin LymphomaRecurrent Childhood Hodgkin LymphomaRecurrent Childhood Non-Hodgkin LymphomaRecurrent Chronic Lymphocytic LeukemiaRecurrent Non-Hodgkin LymphomaRecurrent Small Lymphocytic LymphomaRefractory Childhood Hodgkin LymphomaRefractory Chronic Lymphocytic LeukemiaRefractory Hodgkin LymphomaRefractory Non-Hodgkin LymphomaRefractory Small Lymphocytic LymphomaT-Cell Chronic Lymphocytic LeukemiaT-Cell Prolymphocytic Leukemia

Interventions

PROCEDURE

Autologous Hematopoietic Stem Cell Transplantation

Undergo autologous transplantation

PROCEDURE

Autologous-Allogeneic Tandem Hematopoietic Stem Cell Transplantation

Undergo autologous-allogeneic tandem hematopoietic stem cell transplantation

DRUG

Carmustine

Given IV

DRUG

Cyclophosphamide

Given IV

DRUG

Cyclosporine

Given PO

DRUG

Cytarabine

Given IV

DRUG

Etoposide

Given IV

DRUG

Fludarabine Phosphate

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Melphalan

Given IV

DRUG

Mycophenolate Mofetil

Given PO

PROCEDURE

Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation

Undergo allogeneic transplantation

PROCEDURE

Peripheral Blood Stem Cell Transplantation

Undergo allogeneic transplantation

BIOLOGICAL

Therapeutic Autologous Lymphocytes

IV donor lymphocyte infusion

RADIATION

Total-Body Irradiation

Undergo radiotherapy

Trial Locations (5)

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84143

LDS Hospital, Salt Lake City

98101

VA Puget Sound Health Care System, Seattle

98109

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle

D-04103

Universitaet Leipzig, Leipzig

All Listed Sponsors

collaborator

National Cancer Institute (NCI)

NIH

lead

Fred Hutchinson Cancer Center

OTHER