302
Participants
Start Date
August 31, 1998
Primary Completion Date
May 31, 2001
Study Completion Date
August 31, 2003
Inhaled Nitric Oxide
Study gas was initiated at a concentration of 5 ppm, and the dose was increased to 20 ppm when the infant had \<=20 mm Hg increase in PaO2 (less than full response).
Standard iNO therapy
Begin a sham initiation of iNO in term and near-term infants in respiratory failure with an oxygenation index (OI) between 15-25; initiated actual iNO therapy based on standard threshold (OI \>=25).
Emory University, Atlanta
University of Miami, Miami
University of Alabama at Birmingham, Birmingham
University of Tennessee, Memphis
Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland
Cincinnati Children's Medical Center, Cincinnati
Indiana University, Indianapolis
Wayne State University, Detroit
University of Texas Southwestern Medical Center at Dallas, Dallas
Texas Children's Hospital, Houston
University of Texas Health Science Center at Houston, Houston
St. Joseph's Hospital, Phoenix
University of New Mexico, Albuquerque
San Diego Children's Hospital, San Diego
Stanford University, Palo Alto
University of Washington School of Medicine, Seattle
Yale University, New Haven
Brown University, Women & Infants Hospital of Rhode Island, Providence
Collaborators (1)
National Center for Research Resources (NCRR)
NIH
Canadian Institutes of Health Research (CIHR)
OTHER_GOV
Mallinckrodt
INDUSTRY
NICHD Neonatal Research Network
NETWORK