838
Participants
Start Date
April 30, 2000
Primary Completion Date
July 31, 2007
cyclophosphamide
Given IV
cytarabine
Deoxycytidine analogue which is metabolized to ARA-CTP, a substance which inhibits DNA polymerase.
daunorubicin hydrochloride
Given IV
dexamethasone
Dexamethasone is a synthetic fluorinated glucocorticoid devoid of mineralocorticoid effects.
leucovorin calcium
Synthetic d,l-5 CHO tetrahydrofolate, which is used to bypass the inhibition of dihydrofolate reductase by Methotrexate (MTX)
mercaptopurine
An analogue of the nucleic acid constituent adenine and the physiological purine base hypoxanthine
methotrexate
A folate analogue which inhibits the enzyme dihydrofolate reductase, haltin g DNA, RNA, and protein synthesis
pegaspargase
E-Coli asparaginase deaminates asparagine, thus, is lethal for cells which cannot synthesize asparagine.
thioguanine
Given orally
vincristine sulfate
Given IV
Children's Hospital at Westmead, Westmead
Royal Children's Hospital, Parkville
Royal Children's Hospital, Brisbane
Mount Sinai Medical Center, New York
Beth Israel Medical Center - Singer Division, New York
Schneider Children's Hospital, New Hyde Park
SUNY Upstate Medical University Hospital, Syracuse
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester
Walter Reed Army Medical Center, Silver Spring
University of Virginia Cancer Center, Charlottesville
Carilion Medical Center for Children at Roanoke Community Hospital, Roanoke
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division, Charleston
Duke Comprehensive Cancer Center, Durham
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte
Mission Hospitals - Memorial Campus, Asheville
Children's Hospital of Greenville Hospital System, Greenville
University of Miami Sylvester Comprehensive Cancer Center, Miami
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus, Atlanta
Nemours Children's Clinic, Jacksonville
Sacred Heart Children's Hospital, Pensacola
Florida Hospital Cancer Institute, Orlando
Nemours Children's Clinic-Orlando, Orlando
Joe DiMaggio Children's Hospital at Memorial, Hollywood
Miami Children's Hospital, Miami
Broward General Medical Center, Fort Lauderdale
Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach
All Children's Hospital, St. Petersburg
Children's Hospital of Southwest Florida, Fort Myers
Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham
University of South Alabama Cancer Research Institute, Mobile
St. Jude Children's Research Hospital, Memphis
Children's Hospital of Michigan, Detroit
Van Elslander Cancer Center at St. John Hospital and Medical Center, Detroit
Hurley Medical Center, Flint
Midwest Children's Cancer Center, Milwaukee
CCOP - Marshfield Clinic Research Foundation, Marshfield
Advocate Hope Children's Hospital, Oak Lawn
Rush University Medical Center, Chicago
Children's Memorial Hospital - Chicago, Chicago
Saint Jude Midwest Affiliate, Peoria
Cardinal Glennon Children's Hospital, St Louis
St. Louis Children's Hospital, St Louis
University of Missouri - Columbia, Columbia
Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita
Wesley Medical Center, Wichita
MBCCOP - LSU Health Sciences Center, New Orleans
Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans
Children's Hospital of New Orleans, New Orleans
Ochsner Cancer Institute at Ochsner Clinic Foundation, New Orleans
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock
Oklahoma University Medical Center, Oklahoma City
Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa
Medical City Dallas Hospital, Dallas
Cook Children's Medical Center - Fort Worth, Fort Worth
CCOP - Scott and White Hospital, Temple
Center for Cancer Prevention and Care at Scott and White Clinic, Temple
University of Texas Health Science Center at San Antonio, San Antonio
San Antonio Military Pediatric Cancer and Blood Disorders Center, Lackland Air Force Base
Driscoll Children's Hospital, Corpus Christi
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson
University of New Mexico Cancer Research and Treatment Center, Albuquerque
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego
Sutter Cancer Center, Sacramento
University of California Davis Cancer Center, Sacramento
Cancer Research Center of Hawaii, Honolulu
CCOP - Columbia River Oncology Program, Portland
Legacy Emanuel Hospital and Health Center & Children's Hospital, Portland
Rebecca and John Moores UCSD Cancer Center, La Jolla
Stanford Cancer Center at Stanford University Medical Center, Palo Alto
Children's Hospital and Health Center - San Diego, San Diego
Kaiser Permanente Medical Center - Santa Clara Kiely Campus, Santa Clara
Yale Comprehensive Cancer Center, New Haven
University of Florida Shands Cancer Center, Gainesville
Baptist-South Miami Regional Cancer Program, Miami
St. Joseph's Children's Hospital of Tampa, Tampa
MBCCOP-Medical College of Georgia Cancer Center, Augusta
Tripler Army Medical Center, Honolulu
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City
CCOP - Wichita, Wichita
Pediatric Specialty Clinic at Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program, Scarborough
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Floating Hospital for Children, Boston
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston
UMASS Memorial Cancer Center - University Campus, Worcester
University of Mississippi Medical Center, Jackson
Keesler Medical Center - Keesler Air Force Base, Keesler Air Force Base
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon
Hackensack University Medical Center, Hackensack
Roswell Park Cancer Institute, Buffalo
Long Island Cancer Center at Stony Brook University Hospital, Stony Brook
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital, Greenville
Comprehensive Cancer Center at Wake Forest University, Winston-Salem
St. Christopher's Hospital for Children, Philadelphia
Rhode Island Hospital, Providence
Hollings Cancer Center at Medical University of South Carolina, Charleston
East Tennessee State University Cancer Center at Johnson City Medical Center, Johnson City
Simmons Cancer Center at University of Texas Southwestern Medical Center at Dallas, Dallas
University of Texas Medical Branch, Galveston
Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital, Houston
MBCCOP - South Texas Pediatrics, San Antonio
Vermont Cancer Center at University of Vermont, Burlington
INOVA Fairfax Hospital, Falls Church
Naval Medical Center - Portsmouth, Portsmouth
Massey Cancer Center at Virginia Commonwealth University, Richmond
Madigan Army Medical Center, Tacoma
Mary Babb Randolph Cancer Center at West Virginia University Hospitals, Morgantown
St. Vincent Hospital, Green Bay
Alberta Children's Hospital, Calgary
Cross Cancer Institute at University of Alberta, Edmonton
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
Montreal Children's Hospital at McGill University Health Center, Montreal
Hopital Sainte Justine, Montreal
Centre de Recherche du Centre Hospitalier de l'Universite Laval, Sainte-Foy
University Medical Center Groningen, Groningen
San Jorge Children's Hospital, Santurce
Swiss Pediatric Oncology Group Bern, Bern
Swiss Pediatric Oncology Group Geneva, Geneva
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK