Hormone Therapy and Radiation Therapy in Treating Patients With Prostate Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

1,579

Participants

Timeline

Start Date

February 29, 2000

Primary Completion Date

September 30, 2012

Study Completion Date

May 20, 2022

Conditions
Prostate Cancer
Interventions
DRUG

Casodex

Orally at a dose of one 50 mg tablet per day started within (before or after) 14 days of the first LHRH agonist injection.

DRUG

Eulexin

Orally at a dose of two 125 mg capsules three times a day for a total daily dose of 750 mg (six capsules) started within (before or after) 14 days of the first LHRH agonist injection.

DRUG

LHRH agonist

LHRH agonist of choice. The manufacturer's instructions should be followed.

RADIATION

radiation therapy

\[Prostate and any extraprostatic tumor extension + 1.0-1.5 cm margin receives 70.2 Gy (1.8 Gy/day x 39 fractions, five days/week)\] OR \[regional nodes, prostate and seminal vesicles + 1.0-1.5 cm margin will receive 46.8 Gy (1.8 Gy/day x 26 fractions, five days/week), followed by a 23.4 Gy (1.8 Gy/day x 13 fractions, five days/week) boost to the prostate and any extraprostatic tumor extension + 1.0-1.5 cm margin\]

Trial Locations (261)

10003

Beth Israel Medical Center - Philipps Ambulatory Care Center, New York

10032

Herbert Irving Comprehensive Cancer Center at Columbia University, New York

10701

Riverhill Radiation Oncology, Yonkers

11030

CCOP - North Shore University Hospital, Manhasset

11203

State University of New York Health Science Center at Brooklyn, Brooklyn

11215

New York Methodist Hospital, Brooklyn

12208

Cancer Center of Albany Medical Center, Albany

13217

CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse

14432

Finger Lakes Radiation Oncology Center, Clifton Springs

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

15212

Allegheny General Hospital, Pittsburgh

15219

Mercy Hospital of Pittsburgh, Pittsburgh

15224

Western Pennsylvania Hospital, Pittsburgh

15236

Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh

17403

Wellspan Health - York Cancer Center, York

18015

St. Luke's Hospital Cancer Center, Bethlehem

18105

John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown

18301

Pocono Cancer Center, East Stroudsburg

18501

Mercy Hospital Cancer Center - Scranton, Scranton

19001

Abington Memorial Hospital, Abington

19023

Mercy Fitzgerald Hospital, Darby

19026

Delaware County Memorial Hospital, Drexel Hill

19096

CCOP - MainLine Health, Wynnewood

19104

Veterans Affairs Medical Center - Philadelphia, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19713

CCOP - Christiana Care Health Services, Newark

20016

Sibley Memorial Hospital, Washington D.C.

21201

Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore

21204

Greater Baltimore Medical Center and Cancer Center, Baltimore

21215

Sinai Hospital of Baltimore, Baltimore

21229

St. Agnes Cancer Center, Baltimore

21401

Anne Arundel Oncology Center, Annapolis

21801

Peninsula Regional Medical Center, Salisbury

22801

RMH Regional Cancer Center, Harrisonburg

22908

Cancer Center at the University of Virginia, Charlottesville

23226

Bon Secours - St. Mary's Hospital, Richmond

26003

Schiffler Cancer Center, Wheeling

28025

Batte Cancer Center at Northeast Medical Center, Concord

29303

CCOP - Upstate Carolina, Spartanburg

29615

CCOP - Greenville, Greenville

30165

Regional Radiation Oncology Center at Rome, Rome

30322

Winship Cancer Institute of Emory University, Atlanta

31901

Medical Center/John B. Amos Community Cancer Center, Columbus

32207

Florida Radiation Oncology Group, Jacksonville

32308

Tallahassee Memorial Hospital, Tallahassee

32401

Bay Medical Center, Panama City

33136

University of Miami Sylvester Cancer Center, Miami

33140

CCOP - Mount Sinai Medical Center, Miami Beach

34233

Sarasota Radiation and Medical Oncology Center, Sarasota

35401

DCH Cancer Treatment Center, Tuscaloosa

35801

Comprehensive Cancer Institute, Huntsville

35807

Huntsville Hospital, Huntsville

36607

MBCCOP - Gulf Coast, Mobile

38301

West Tennessee Cancer Center at Jackson-Madison County General Hospital, Jackson

40202

James Graham Brown Cancer Center at University of Louisville, Louisville

40215

Louisville Radiation Oncology Center at Caritas Regional Cancer Center, Louisville

40503

Central Baptist Hospital, Lexington

41017

St. Elizabeth Medical Center, Edgewood

42431

Merle M. Mahr Cancer Center, Madisonville

43206

CCOP - Columbus, Columbus

44106

University Hospitals of Cleveland, Cleveland

44129

Parma Community General Hospital, Parma

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

44302

Akron General Medical Center, Akron

44304

Akron City Hospital, Akron

45219

Cancer Center at Christ Hospital, Cincinnati

Charles M. Barrett Cancer Center at University Hospital, Cincinnati

45429

CCOP - Dayton, Dayton

46016

St. John's Medical Center, Anderson

46202

Veterans Affairs Medical Center - Indianapolis (Roudebush), Indianapolis

46219

Community Regional Cancer Care, Indianapolis

46601

CCOP - Northern Indiana CR Consortium, South Bend

47402

Bloomington Hospital, Bloomington

48073

William Beaumont Hospital - Royal Oak, Royal Oak

48085

William Beaumont Hospital - Troy, Troy

48106

CCOP - Michigan Cancer Research Consortium, Ann Arbor

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

48503

Hurley Medical Center, Flint

48670

MidMichigan Medical Center - Midland, Midland

49855

Marquette General Hospital, Marquette

52001

Wendt Regional Cancer Center of Finley Hospital, Dubuque

53051

Community Memorial Hospital, Menomonee Falls

53188

Waukesha Memorial Hospital Regional Cancer Center, Waukesha

53211

Columbia Hospital, Milwaukee

53215

St. Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin Cancer Center, Milwaukee

53295

Veterans Affairs Medical Center - Milwaukee (Zablocki), Milwaukee

53405

All Saints Cancer Center at All Saints Healthcare, Racine

53713

Southern Wisconsin Radiotherapy Center, Madison

53792

University of Wisconsin Comprehensive Cancer Center, Madison

54301

CCOP - St. Vincent Hospital Cancer Center, Green Bay, Green Bay

54449

CCOP - Marshfield Clinic Research Foundation, Marshfield

Marshfield Clinic, Marshfield

54601

Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse

55416

CCOP - Metro-Minnesota, Saint Louis Park

55455

Fairview University Medical Center - University Campus, Minneapolis

57709

Rapid City Regional Hospital, Rapid City

58701

Trinity Cancer Care Center, Minot

59101

CCOP - Montana Cancer Consortium, Billings

60005

Northwest Community Hospital, Arlington Heights

60068

Lutheran General Cancer Care Center, Park Ridge

60153

Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood

60426

Ingalls Memorial Hospital, Harvey

61602

CCOP - Scott and White Hospital, Peoria

61636

Methodist Medical Center of Illinois, Peoria

62526

CCOP - Central Illinois, Decatur

63110

Mallinckrodt Institute of Radiology, St Louis

64131

CCOP - Kansas City, Kansas City

65203

Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia

65807

Cancer Research for the Ozarks, Springfield

CCOP - Cancer Research for the Ozarks, Springfield

68106

CCOP - Missouri Valley Cancer Consortium, Omaha

70112

MBCCOP - LSU Health Sciences Center, New Orleans

70121

CCOP - Ochsner, New Orleans

70809

Mary Bird Perkins Cancer Center, Baton Rouge

73102

Frank C. Love Cancer Institute at St. Anthony Hospital, Oklahoma City

73104

Oklahoma University Medical Center at University of Oklahoma Health Sciences Center, Oklahoma City

74104

St. John Health System, Tulsa

74136

CCOP - Oklahoma, Tulsa

76012

Arlington Cancer Center, Arlington

77504

Bayshore Medical Center, Pasadena

79106

Harrington Cancer Center, Amarillo

80010

University of Colorado Cancer Center at University of Colorado Health Sciences Center, Denver

80224

CCOP - Colorado Cancer Research Program, Incorporated, Denver

80909

Memorial Hospital Cancer Center, Colorado Springs

84132

University of Utah Health Sciences Center, Salt Lake City

84143

LDS Hospital, Salt Lake City

84604

Utah Valley Regional Medical Center - Provo, Provo

84770

Dixie Regional Medical Center, St. George

85013

Foundation for Cancer Research and Education, Phoenix

87109

Radiation Oncology Associates of Albuquerque, Albuquerque

89106

CCOP - Southern Nevada Cancer Research Foundation, Las Vegas

89109

Comprehensive Cancer Centers of Nevada, Las Vegas

90505

Torrance Memorial Medical Center, Torrance

90822

Veterans Affairs Medical Center - Long Beach, Long Beach

91105

Huntington Cancer Center at Huntington Hospital, Pasadena

91505

Providence Saint Joseph Medical Center - Burbank, Burbank

91767

Robert and Beverly Lewis Family Cancer Care Center, Pomona

92101

Radiation Medical Group, Incorporated, San Diego

92354

Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda

93720

California Cancer Center, Fresno

Saint Agnes Cancer Center, Fresno

94115

UCSF Comprehensive Cancer Center, San Francisco

94535

David Grant Medical Center, Travis Air Force Base

94904

Sutter Health Western Division Cancer Research Group, Greenbrae

95128

O'Connor Hospital, San Jose

95403

CCOP - Santa Rosa Memorial Hospital, Santa Rosa

95816

Radiation Oncology Center - Sacramento, Sacramento

96813

MBCCOP - Hawaii, Honolulu

97225

CCOP - Columbia River Oncology Program, Portland

98111

Cancer Institute at Virginia Mason Medical Center, Seattle

98902

Yakima Valley Memorial Hospital, Yakima

99204

Deaconess Medical Center, Spokane

35294-3300

University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham

36106-3657

Montgomery Cancer Center, Montgomery

94524-4110

Mount Diablo Medical Center, Concord

91010-3000

City of Hope Comprehensive Cancer Center, Duarte

90033-0804

USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles

90095-1714

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles

94609-3305

CCOP - Bay Area Tumor Institute, Oakland

92134-3202

Naval Medical Center - San Diego, San Diego

81502-1628

St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center, Grand Junction

06511

Hospital of St. Raphael, New Haven

06520-8040

Yale Comprehensive Cancer Center, New Haven

33901-8082

21st Century Oncology - Fort Myers, Fort Myers

32610-0385

Shands Cancer Center at the University of Florida Health Science Center, Gainesville

32901-3276

Holmes Regional Medical Center, Melbourne

33256-2110

Baptist Hospital of Miami, Miami

32806-2134

MD Anderson Cancer Center Orlando, Orlando

32405-4587

Gulf Coast Cancer Treatment Center, Panama City

33612-9497

H. Lee Moffitt Cancer Center and Research Institute, Tampa

30342-1701

CCOP - Atlanta Regional, Atlanta

60611-3013

Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago

46206-1367

Methodist Cancer Center at Methodist Hospital, Indianapolis

47303-3499

Ball Memorial Hospital Cancer Center, Muncie

40536-0293

Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington

70112-2699

Tulane University School of Medicine, New Orleans

04102

Maine Medical Center, Portland

21215-1290

Harbor Hospital Center, Baltimore

21231-2410

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

02114

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

02118

Cancer Research Center at Boston Medical Center, Boston

02601

Cape Cod Hospital, Hyannis

02130

Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain

01960

NSMC Cancer Center, Peabody

48109-0010

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

48532-3685

McLaren Regional Cancer Center, Flint

49007-3731

CCOP - Kalamazoo, Kalamazoo

48073-6769

CCOP - Beaumont, Royal Oak

55905-0001

Mayo Clinic Cancer Center, Rochester

63110-0250

St. Louis University Hospital Cancer Center, St Louis

68114-4199

Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha

68198-7521

UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha

03756-0002

Norris Cotton Cancer Center at Dartmouth Medical School, Lebanon

03103

Elliot Regional Cancer Center, Manchester

01803

Cooper Cancer Institute, Camden

07019

Veterans Affairs Medical Center - East Orange, East Orange

08818

John F. Kennedy Medical Center, Edison

07201

Trinitas Hospital - Jersey Street Campus, Elizabeth

07740-6395

Monmouth Medical Center, Long Branch

08332

South Jersey Regional Cancer Center, Millville

08060

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital, Mount Holly

08903

Cancer Institute of New Jersey, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

08240

Atlantic City Medical Center, Pomona

08540

Medical Center of Princeton, Princeton

07450

Valley Hospital, Ridgewood

08876

Somerset Medical Center, Somerville

08755

Community Medical Center, Toms River

08629

Fox Chase Cancer Center at St. Francis Medical Center, Trenton

07059

Associated Radiologists, P.A., Warren Township

14263-0001

Roswell Park Cancer Institute, Buffalo

12901-1490

Champlain Valley Physicians Hospital Medical Center, Plattsburgh

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

27835-6028

Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina, Greenville

27104-4241

CCOP - Southeast Cancer Control Consortium, Winston-Salem

27157-1082

Comprehensive Cancer Center at Wake Forest University, Winston-Salem

44106-5065

Ireland Cancer Center, Cleveland

43210-1240

Arthur G. James Cancer Hospital - Ohio State University, Columbus

43623-3456

CCOP - Toledo Community Hospital, Toledo

17822-2001

Geisinger Medical Center, Danville

17033-0850

Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey

19104-4283

Abramson Cancer Center at University of Pennsylvania Medical Center, Philadelphia

19107-5541

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia

19141-3098

Albert Einstein Cancer Center, Philadelphia

19612-6052

Reading Hospital and Medical Center, Reading

18764-0001

Wilkes-Barre General Hospital, Wilkes-Barre

02908-4735

Roger Williams Medical Center, Providence

37232-5671

Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center, Nashville

77555-0209

University of Texas Medical Branch, Galveston

77030-4009

University of Texas - MD Anderson Cancer Center, Houston

78236-5300

Wilford Hall Medical Center, Lackland Air Force Base

79410-1894

Joe Arrington Cancer Research and Treatment Center, Lubbock

78284-7811

University of Texas Health Science Center at San Antonio, San Antonio

05201

Green Mountain Oncology Group, Bennington

05405-0075

Vermont Cancer Center at University of Vermont, Burlington

23708-2197

Naval Medical Center, Portsmouth, Portsmouth

23298-0058

Massey Cancer Center at Virginia Commonwealth University, Richmond

98195-6043

University Cancer Center at University of Washington Medical Center, Seattle

54307-3508

St. Vincent Hospital, Green Bay

T2N 4N2

Tom Baker Cancer Center - Calgary, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

E1C 8X3

Doctor Leon Richard Oncology Centre, Moncton

E2L 4L2

Saint John Regional Hospital, Saint John

A1B 3V6

Newfoundland Cancer Treatment and Research Foundation, St. John's

B3H 1V7

Nova Scotia Cancer Centre, Halifax

P3E 5J1

Northeastern Ontario Regional Cancer Centre - Sudbury, Greater Sudbury

L8V 5C2

Margaret and Charles Juravinski Cancer Centre, Hamilton

K7L 5P9

Kingston Regional Cancer Centre, Kingston

N6A 4L6

Cancer Care Ontario-London Regional Cancer Centre, London

K1H 1C4

Ottawa Regional Cancer Centre, Ottawa

P7B 6V4

Northwestern Ontario Regional Cancer Care, Thunder Bay

M4N 3M5

Toronto Sunnybrook Regional Cancer Centre, Toronto

M5G 2M9

Princess Margaret Hospital, Toronto

J1H 5N4

CHUS-Hopital Fleurimont, Fleurimont

H2L 4MI

Centre Hospitalier de l'Universite de Montreal, Montreal

H2W 1S6

McGill University, Montreal

G1R 2J6

Centre Hospitalier Universitaire de Quebec, Québec

S4T 7T1

Allan Blair Cancer Centre, Regina

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Radiation Therapy Oncology Group

NETWORK

NCT00005044 - Hormone Therapy and Radiation Therapy in Treating Patients With Prostate Cancer | Biotech Hunter | Biotech Hunter