The Diabetes Prevention Trial of Type 1 Diabetes (DPT-1)

PHASE3CompletedINTERVENTIONAL
Enrollment

711

Participants

Timeline

Start Date

February 28, 1994

Primary Completion Date

June 30, 2003

Study Completion Date

June 30, 2003

Conditions
Diabetes Mellitus, Type 1
Interventions
DRUG

Parenteral Insulin

Subcutaneous injections of recombinant human ultralente insulin in the morning and in the evening; the initial dose for each injection was 0.125 U per kilogram of body weight.

OTHER

Close Observation

Study visits every 6 months including an oral glucose tolerance test

DRUG

Oral Insulin

Capsules oral insulin, 7.5 mg of recombinant human insulin crystals

DRUG

Placebo

Placebo for oral insulin

Trial Locations (15)

10032

Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Ave, New York

15213

Children's Hospital of Pittsburgh, Dept/Pediatric Endocrinology, 3705 5th Ave, Pittsburgh

33136

DPT-1 Operations Coordinating Center, Miami

University of Miami School of Medicine, Jackson Medical Tower, Miami

46202

Indiana University, James Whitcomb Riley Hospital for Children, 702 Barnhill Dr, Ste 5960, Indianapolis

55455

University of Minnesota, Minneapolis

75235

University of Texas, Children's Medical Center, 6300 Harry Hines Ste 1200, Dallas

80262

University of Colorado Barbara Davis Center for Childhood Diabetes, Denver

90027

Childrens Hospital of Los Angeles, Division of Endocrinology, Los Angeles

94143

University of California-San Francisco, Milberry Union East RM 405, 500 Parnassus Ave Box 0136, San Francisco

98101

Virginia Mason Research Center, 1201 Ninth Avenue, Seattle

94305-5208

Stanford University, Stanford

32610-0296

University of Florida Diabetes Research Center, Gainesville

02215

Joslin Diabetes Center, Boston

M5G-1X8

Hospital for Sick Children, Division of Endocrinology, 555 University Ave, Rm 5110, Toronto

All Listed Sponsors
collaborator

National Center for Research Resources (NCRR)

NIH

collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

collaborator

National Institute on Minority Health and Health Disparities (NIMHD)

NIH

collaborator

Office of Research on Women's Health (ORWH)

NIH

lead

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH