Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen

PHASE3CompletedINTERVENTIONAL
Enrollment

173

Participants

Timeline

Start Date

June 30, 1998

Primary Completion Date

November 30, 2006

Study Completion Date

November 30, 2006

Conditions
Acute Liver Failure
Interventions
DRUG

N-acetylcysteine (NAC)

Infusion of 5% dextrose with N-acetylcysteine with an initial loading dose of 150 mg/kg/h of NAC over 1 hour, followed by 12.5 mg/kg/h for 4 hours, then continuous infusions of 6.25 mg/kg/h for the remaining 67 hours.

DRUG

Placebo

Infusion of 5% dextrose

Trial Locations (25)

10029

Mount Sinai Medical Center, NY, New York

15213

University of Pittsburgh Medical Center, Pittsburgh

19104

University of Pennsylvania, Philadelphia

19141

Albert Einstein Medical Center, Philadelphia

27715

Duke University Medical Center, Durham

29425

Medical University of South Carolina, Charleston

32216

Mayo Clinic, Jacksonville

48109

University of Michigan Health Systems, Ann Arbor

55905

Mayo Clinic, Rochester

60611

Northwestern University Medical School, Chicago

63110

Washington University School of Medicine, St Louis

75246

Baylor University Medical Center, Dallas

85259

Mayo Clinic, Scottsdale

90024

University of California Los Angeles, Los Angeles

94115

University of California San Francisco, San Francisco

95817

University of California Davis, Sacramento

35294-0005

University of Alabama at Birmingham, Birmingham

92103-0707

University of California San Diego, San Diego

02114

Massachusetts General Hospital, Boston

68198-3330

University of Nebraska Medical Center, Omaha

10032-3784

New York Presbyterian Hospital, New York

97201-3098

Oregon Health Sciences University, Portland

75235-8897

University of Texas Southwestern Medical Center at Dallas, Dallas

23298-0341

Virginia Commonwealth University, Richmond

98195-6043

University of Washington Medical Center, Seattle

All Listed Sponsors
collaborator

University of Texas Southwestern Medical Center

OTHER

lead

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

NCT00004467 - Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen | Biotech Hunter | Biotech Hunter