Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation

PHASE2/PHASE3CompletedINTERVENTIONAL
Timeline

Start Date

March 31, 2000

Study Completion Date

May 31, 2003

Conditions
Graft Versus Host DiseaseLeukemiaMyelodysplastic Syndromes
Interventions
BIOLOGICAL

anti-thymocyte globulin

BIOLOGICAL

filgrastim

DRUG

cyclophosphamide

DRUG

fludarabine phosphate

DRUG

methylprednisolone

DRUG

tacrolimus

PROCEDURE

allogeneic bone marrow transplantation

PROCEDURE

in vitro-treated bone marrow transplantation

RADIATION

radiation therapy

Trial Locations (15)

10595

New York Medical College, Valhalla

14642

University of Rochester Cancer Center, Rochester

20007

Lombardi Cancer Center, Washington D.C.

40202

James Graham Brown Cancer Center, Louisville

46202

Indiana Blood and Marrow Transplantation, Indianapolis

73190

University of Oklahoma Health Sciences Center, Oklahoma City

78229

South Texas Cancer Institute, San Antonio

80218

Presbyterian-St Luke's Medical Center, Denver

92093-0658

University of California San Diego Cancer Center, La Jolla

32610-100277

Shands Hospital and Clinics, University of Florida, Gainesville

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

97201-3098

Oregon Cancer Center, Portland

19102-1192

Hahnemann University Hospital, Philadelphia

77030-4009

University of Texas - MD Anderson Cancer Center, Houston

23298-0037

Massey Cancer Center, Richmond

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Chimeric Therapies

INDUSTRY