495
Participants
Start Date
February 28, 2001
Primary Completion Date
October 31, 2007
filgrastim
Given IV
carboplatin
Given IV
cisplatin
Given IV
cyclophosphamide
Given IV
doxorubicin hydrochloride
Given IV
etoposide
Given IV
isotretinoin
Given IV
melphalan
Given IV
topotecan hydrochloride
Given IV
vincristine sulfate
Given IV
autologous bone marrow transplantation
bone marrow ablation with stem cell support
conventional surgery
All patients undergo delayed surgical resection of the residual tumor after course 5 of induction chemotherapy
peripheral blood stem cell transplantation
radiation therapy
After completion of consolidation (at least 28 days from stem cell infusion), all patients receive local radiotherapy daily over 7 days
NYU Cancer Institute at New York University Medical Center, New York
New York Medical College, Valhalla
Children's Hospital of Pittsburgh, Pittsburgh
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore
Carilion Cancer Center of Western Virginia, Roanoke
Edwards Comprehensive Cancer Center at Cabell Huntington Hospital, Huntington
Mary Babb Randolph Cancer Center at West Virginia University Hospitals, Morgantown
Duke Comprehensive Cancer Center, Durham
Mission Hospitals - Memorial Campus, Asheville
Palmetto Health South Carolina Cancer Center, Columbia
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood
Broward General Medical Center Cancer Center, Fort Lauderdale
Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach
St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa
All Children's Hospital, St. Petersburg
Lee Cancer Care of Lee Memorial Health System, Fort Myers
Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham
East Tennessee Children's Hospital, Knoxville
Kosair Children's Hospital, Louisville
Toledo Hospital, Toledo
Medical College of Ohio Cancer Institute, Toledo
St. Vincent Indianapolis Hospital, Indianapolis
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods
Breslin Cancer Center at Ingham Regional Medical Center, Lansing
Blank Children's Hospital, Des Moines
Midwest Children's Cancer Center, Milwaukee
Marshfield Clinic - Marshfield Center, Marshfield
Children's Hospital of Minnesota - Minneapolis, Minneapolis
Fairview University Medical Center - University Campus, Minneapolis
Children's Memorial Hospital - Chicago, Chicago
Siteman Cancer Center at Barnes-Jewish Hospital, St Louis
Children's Mercy Hospital, Kansas City
Children's Hospital of Austin, Austin
Texas Tech University Health Sciences Center School of Medicine, Amarillo
Covenant Children's Hospital, Lubbock
Children's Hospital Los Angeles, Los Angeles
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda
UCSF Comprehensive Cancer Center, San Francisco
Stanford Cancer Center at Stanford University Medical Center, Stanford
Kaiser Permanente Medical Center - Oakland, Sacramento
Phoenix Children's Hospital, Phoenix
Southern California Permanente Medical Group, Downey
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles
Children's Hospital Central California, Madera
Children's Hospital and Health Center - San Diego, San Diego
Children's Hospital Cancer Center, Denver
Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington
Children's National Medical Center, Washington D.C.
University of Florida Shands Cancer Center, Gainesville
University of Illinois at Chicago Cancer Center, Chicago
Southern Illinois University School of Medicine, Springfield
Indiana University Cancer Center, Indianapolis
Holden Comprehensive Cancer Center at University of Iowa, Iowa City
Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington
CancerCare of Maine at Eastern Maine Medial Center, Bangor
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston
C.S. Mott Children's Hospital at University of Michigan, Ann Arbor
Spectrum Health Cancer Care - Butterworth Campus, Grand Rapids
CCOP - Kalamazoo, Kalamazoo
Children's Hospital of Omaha, Omaha
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha
Sunrise Hospital and Medical Center, Las Vegas
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon
Cancer Center at Hackensack University Medical Center, Hackensack
St. Barnabas Medical Center, Livingston
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick
Newark Beth Israel Medical Center, Newark
St. Joseph's Hospital and Medical Center, Paterson
University of New Mexico Cancer Research and Treatment Center, Albuquerque
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte
Cincinnati Children's Hospital Medical Center, Cincinnati
Cleveland Clinic Taussig Cancer Center, Cleveland
Columbus Children's Hospital, Columbus
Children's Medical Center - Dayton, Dayton
Cancer Institute at Oregon Health and Science University, Portland
Rhode Island Hospital, Providence
Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls
Cook Children's Medical Center - Fort Worth, Fort Worth
University of Texas Health Science Center at San Antonio, San Antonio
Fletcher Allen Health Care - University Health Center Campus, Burlington
Massey Cancer Center at Virginia Commonwealth University, Richmond
Providence Cancer Center at Sacred Heart Medical Center, Spokane
St. Vincent Hospital Regional Cancer Center, Green Bay
University of Wisconsin Comprehensive Cancer Center, Madison
Alberta Children's Hospital, Calgary
Children's & Women's Hospital of British Columbia, Vancouver
Janeway Children's Health and Rehabilitation Centre, St. John's
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Children's Hospital of Western Ontario, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
McGill Cancer Centre at McGill University, Montreal
Centre Hospitalier Universitaire de Quebec, Ste-Foy
Allan Blair Cancer Centre at Pasqua Hospital, Regina
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK