Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma

PHASE3CompletedINTERVENTIONAL
Enrollment

495

Participants

Timeline

Start Date

February 28, 2001

Primary Completion Date

October 31, 2007

Conditions
Neuroblastoma
Interventions
BIOLOGICAL

filgrastim

Given IV

DRUG

carboplatin

Given IV

DRUG

cisplatin

Given IV

DRUG

cyclophosphamide

Given IV

DRUG

doxorubicin hydrochloride

Given IV

DRUG

etoposide

Given IV

DRUG

isotretinoin

Given IV

DRUG

melphalan

Given IV

DRUG

topotecan hydrochloride

Given IV

DRUG

vincristine sulfate

Given IV

PROCEDURE

autologous bone marrow transplantation

PROCEDURE

bone marrow ablation with stem cell support

PROCEDURE

conventional surgery

All patients undergo delayed surgical resection of the residual tumor after course 5 of induction chemotherapy

PROCEDURE

peripheral blood stem cell transplantation

RADIATION

radiation therapy

After completion of consolidation (at least 28 days from stem cell infusion), all patients receive local radiotherapy daily over 7 days

Trial Locations (96)

10016

NYU Cancer Institute at New York University Medical Center, New York

10595

New York Medical College, Valhalla

15213

Children's Hospital of Pittsburgh, Pittsburgh

21215

Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore

24029

Carilion Cancer Center of Western Virginia, Roanoke

25701

Edwards Comprehensive Cancer Center at Cabell Huntington Hospital, Huntington

26506

Mary Babb Randolph Cancer Center at West Virginia University Hospitals, Morgantown

27710

Duke Comprehensive Cancer Center, Durham

28801

Mission Hospitals - Memorial Campus, Asheville

29203

Palmetto Health South Carolina Cancer Center, Columbia

33021

Memorial Cancer Institute at Memorial Regional Hospital, Hollywood

33316

Broward General Medical Center Cancer Center, Fort Lauderdale

33407

Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach

33607

St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa

33701

All Children's Hospital, St. Petersburg

33901

Lee Cancer Care of Lee Memorial Health System, Fort Myers

35294

Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham

37916

East Tennessee Children's Hospital, Knoxville

40232

Kosair Children's Hospital, Louisville

43606

Toledo Hospital, Toledo

43614

Medical College of Ohio Cancer Institute, Toledo

46260

St. Vincent Indianapolis Hospital, Indianapolis

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods

48910

Breslin Cancer Center at Ingham Regional Medical Center, Lansing

50309

Blank Children's Hospital, Des Moines

53226

Midwest Children's Cancer Center, Milwaukee

54449

Marshfield Clinic - Marshfield Center, Marshfield

55404

Children's Hospital of Minnesota - Minneapolis, Minneapolis

55455

Fairview University Medical Center - University Campus, Minneapolis

60614

Children's Memorial Hospital - Chicago, Chicago

63110

Siteman Cancer Center at Barnes-Jewish Hospital, St Louis

64108

Children's Mercy Hospital, Kansas City

78701

Children's Hospital of Austin, Austin

79106

Texas Tech University Health Sciences Center School of Medicine, Amarillo

79410

Covenant Children's Hospital, Lubbock

90027

Children's Hospital Los Angeles, Los Angeles

90801

Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach

92354

Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda

94115

UCSF Comprehensive Cancer Center, San Francisco

94305

Stanford Cancer Center at Stanford University Medical Center, Stanford

95825

Kaiser Permanente Medical Center - Oakland, Sacramento

85016-7710

Phoenix Children's Hospital, Phoenix

90242-2814

Southern California Permanente Medical Group, Downey

90048-1865

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles

93638-8762

Children's Hospital Central California, Madera

92123-4282

Children's Hospital and Health Center - San Diego, San Diego

80218-1088

Children's Hospital Cancer Center, Denver

06360-2875

Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington

20010-2970

Children's National Medical Center, Washington D.C.

32610-0232

University of Florida Shands Cancer Center, Gainesville

60612-7243

University of Illinois at Chicago Cancer Center, Chicago

62794-9620

Southern Illinois University School of Medicine, Springfield

46202-5289

Indiana University Cancer Center, Indianapolis

52242-1083

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

40536-0084

Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington

04401

CancerCare of Maine at Eastern Maine Medial Center, Bangor

02115

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

48109-0238

C.S. Mott Children's Hospital at University of Michigan, Ann Arbor

49503-2560

Spectrum Health Cancer Care - Butterworth Campus, Grand Rapids

49007-5341

CCOP - Kalamazoo, Kalamazoo

68114-4113

Children's Hospital of Omaha, Omaha

68198-3330

UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha

89109-2306

Sunrise Hospital and Medical Center, Las Vegas

03756-0002

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon

07601

Cancer Center at Hackensack University Medical Center, Hackensack

07039

St. Barnabas Medical Center, Livingston

08903

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

07503

St. Joseph's Hospital and Medical Center, Paterson

87131-5636

University of New Mexico Cancer Research and Treatment Center, Albuquerque

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

28233-3549

Presbyterian Cancer Center at Presbyterian Hospital, Charlotte

45229-3039

Cincinnati Children's Hospital Medical Center, Cincinnati

44195-5217

Cleveland Clinic Taussig Cancer Center, Cleveland

43205-2696

Columbus Children's Hospital, Columbus

45404-1815

Children's Medical Center - Dayton, Dayton

97239-3098

Cancer Institute at Oregon Health and Science University, Portland

02903

Rhode Island Hospital, Providence

57117-5039

Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls

76104-9958

Cook Children's Medical Center - Fort Worth, Fort Worth

78284-7811

University of Texas Health Science Center at San Antonio, San Antonio

05405

Fletcher Allen Health Care - University Health Center Campus, Burlington

23298-0037

Massey Cancer Center at Virginia Commonwealth University, Richmond

99220-2555

Providence Cancer Center at Sacred Heart Medical Center, Spokane

54307-3508

St. Vincent Hospital Regional Cancer Center, Green Bay

53792-6164

University of Wisconsin Comprehensive Cancer Center, Madison

T2T 5C7

Alberta Children's Hospital, Calgary

V6H 3V4

Children's & Women's Hospital of British Columbia, Vancouver

A1B 3V6

Janeway Children's Health and Rehabilitation Centre, St. John's

L8N 3Z5

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

N6A 4G5

Children's Hospital of Western Ontario, London

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

McGill Cancer Centre at McGill University, Montreal

G1V 4G2

Centre Hospitalier Universitaire de Quebec, Ste-Foy

S4T 7T1

Allan Blair Cancer Centre at Pasqua Hospital, Regina

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00004188 - Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma | Biotech Hunter | Biotech Hunter