Doxorubicin and Cyclophosphamide Plus Paclitaxel With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2

PHASE3CompletedINTERVENTIONAL
Enrollment

2,130

Participants

Timeline

Start Date

February 29, 2000

Primary Completion Date

March 31, 2005

Study Completion Date

November 30, 2019

Conditions
Breast Cancer
Interventions
BIOLOGICAL

herceptin

4 mg/kg loading dose then 2 mg/kg weekly for 1 year.

DRUG

adriamycin

60 mg/m2 IV push every 21 days for 4 cycles.

DRUG

cyclophosphamide

600 mg/m2 IV every 21 days for 4 cycles

DRUG

taxol

175 mg/m2 IV every 21 days for 4 cycles

Trial Locations (149)

10305

Nalitt Cancer Institute at Staten Island University Hospital, Staten Island

10451

Lincoln Medical and Mental Health Center, The Bronx

10466

MBCCOP-Our Lady of Mercy Cancer Center, The Bronx

12208

New York Oncology Hematology, P.C. at Albany Regional Cancer Care, Albany

12801

Charles R. Wood Cancer Center at Glens Falls Hospital, Glens Falls

13217

CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse

17315

York Cancer Center at Wellspan Health, York

18103

John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown

18501

Mercy Hospital Cancer Center - Scranton, Scranton

19141

Albert Einstein Cancer Center, Philadelphia

19899

CCOP - Christiana Care Health Services, Wilmington

21237

Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center, Baltimore

23507

Sentara Cancer Institute at Sentara Norfolk General Hospital, Norfolk

26102

Camden-Clark Memorial Hospital, Parkersburg

27216

Alamance Cancer Center, Burlington

29303

CCOP - Upstate Carolina, Spartanburg

29615

CCOP - Greenville, Greenville

30322

Winship Cancer Institute of Emory University, Atlanta

31701

Phoebe Cancer Center at Phoebe Putney Memorial Hospital, Albany

32114

Halifax Medical Center, Daytona Beach

32207

Baptist Cancer Institute - Jacksonville, Jacksonville

32806

M.D. Anderson Cancer Center - Orlando, Orlando

33136

University of Miami Sylvester Comprehensive Cancer Center, Miami

33140

CCOP - Mount Sinai Medical Center, Miami Beach

33324

Cancer Research Network, Inc., Plantation

33756

Morton Plant Hospital, Clearwater

34236

Florida Cancer Specialists, Sarasota

35801

Comprehensive Cancer Institute, Huntsville

40207

Consultants in Blood Disorders and Cancer, Louisville

43206

CCOP - Columbus, Columbus

44122

South Pointe Hospital Cancer Care Center, Cleveland

44309

Akron City Hospital at Summa Health System, Akron

44501

Cancer Care Center at Northside Medical Center, Youngstown

44710

Aultman Hospital Cancer Center at Aultman Health Foundation, Canton

45236

Cancer Center at Jewish Hospital, Cincinnati

45429

CCOP - Dayton, Kettering

46321

Community Hospital, Munster

46601

CCOP - Northern Indiana CR Consortium, South Bend

48073

William Beaumont Hospital - Royal Oak, Royal Oak

48106

CCOP - Michigan Cancer Research Consortium, Ann Arbor

48202

Josephine Ford Cancer Center at Henry Ford Health System, Detroit

48824

Michigan State University, East Lansing

49503

CCOP - Grand Rapids, Grand Rapids

52803

Genesis Regional Cancer Center at Genesis Medical Center, Davenport

53226

Medical College of Wisconsin Cancer Center, Milwaukee

54449

CCOP - Marshfield Clinic Research Foundation, Marshfield

55415

Hennepin County Medical Center - Minneapolis, Minneapolis

55416

CCOP - Metro-Minnesota, Saint Louis Park

55805

CCOP - Duluth, Duluth

57104

CCOP - Sioux Community Cancer Consortium, Sioux Falls

58122

CCOP - Merit Care Hospital, Fargo

59101

CCOP - Montana Cancer Consortium, Billings

60201

CCOP - Evanston, Evanston

60302

West Suburban Hospital Medical Center, Oak Park

60612

Rush Cancer Institute at Rush University Medical Center, Chicago

60657

Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago

61602

CCOP - Illinois Oncology Research Association, Peoria

61801

CCOP - Carle Cancer Center, Urbana

62526

CCOP - Central Illinois, Decatur

63131

Missouri Baptist Cancer Center, St Louis

63141

CCOP - St. Louis-Cape Girardeau, St Louis

64131

CCOP - Kansas City, Kansas City

65203

Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia

65807

CCOP - Cancer Research for the Ozarks, Springfield

68114

Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha

68131

CCOP - Missouri Valley Cancer Consortium, Omaha

70112

Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans, New Orleans

Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans

70121

CCOP - Ochsner, New Orleans

74136

CCOP - Oklahoma, Tulsa

75230

Medical City Dallas Hospital, Dallas

76508

CCOP - Scott and White Hospital, Temple

77030

Baylor College of Medicine, Houston

80010

University of Colorado Cancer Center at University of Colorado Health Sciences Center, Denver

83814

North Idaho Cancer Center, Coeur d'Alene

84604

Utah Valley Regional Medical Center - Provo, Provo

87131

University of New Mexico Cancer Research and Treatment Center, Albuquerque

89106

CCOP - Southern Nevada Cancer Research Foundation, Las Vegas

90813

Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach, Long Beach

92037

Scripps Cancer Center at Scripps Clinic, La Jolla

92120

Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego

92262

Comprehensive Cancer Center at Desert Regional Medical Center, Palm Springs

92354

Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda

92868

Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center, Orange

94589

Kaiser Permanente Medical Center - Vallejo, Vallejo

94904

Sutter Health Western Division Cancer Research Group, Greenbrae

95403

CCOP - Santa Rosa Memorial Hospital, Santa Rosa

95816

Sutter Cancer Center, Sacramento

96813

Cancer Research Center of Hawaii, Honolulu

97213

CCOP - Columbia River Oncology Program, Portland

98101

CCOP - Virginia Mason Research Center, Seattle

98109

Puget Sound Oncology Consortium, Seattle

99519-6604

Providence Alaska Medical Center, Anchorage

85006-2726

CCOP - Western Regional, Arizona, Phoenix

91010-3000

City of Hope Comprehensive Cancer Center, Duarte

94609-3305

CCOP - Bay Area Tumor Institute, Oakland

80209-5031

CCOP - Colorado Cancer Research Program, Incorporated, Denver

06360-7106

Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington

06102-5037

Helen and Harry Gray Cancer Center at Hartford Hospital, Hartford

30342-1701

CCOP - Atlanta Regional, Atlanta

30912-4000

MBCCOP-Medical College of Georgia Cancer Center, Augusta

30905-5650

Dwight David Eisenhower Army Medical Center, Fort Gordon

60612-9985

John H. Stroger, Jr. Hospital of Cook County, Chicago

46206-1367

Methodist Cancer Center at Methodist Hospital, Indianapolis

50309-1016

CCOP - Iowa Oncology Research Association, Des Moines

52242-1009

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

67214-3882

CCOP - Wichita, Wichita

40536-0093

Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington

40202-5070

Norton Cancer Center at Norton Hospital, Louisville

04401

CancerCare of Maine at Eastern Maine Medial Center, Bangor

20889-5000

National Naval Medical Center, Bethesda

02118

Cancer Research Center at Boston Medical Center, Boston

01201

Berkshire Medical Center, Pittsfield

01199

Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield

01655

UMASS Memorial Cancer Center - University Campus, Worcester

49007-3731

CCOP - Kalamazoo, Kalamazoo

48075-9975

Providence Cancer Institute at Providence Hospital - Southfield Campus, Southfield

63110-0250

Saint Louis University Cancer Center, St Louis

07601

CCOP - Northern New Jersey, Hackensack

08903

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

27858-4354

Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital, Greenville

27104-4241

CCOP - Southeast Cancer Control Consortium, Winston-Salem

27157-1082

Comprehensive Cancer Center at Wake Forest University, Winston-Salem

45267-0502

Charles M. Barrett Cancer Center at University Hospital, Cincinnati

44106-5065

Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland

43210-1240

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University, Columbus

17822-2001

Geisinger Medical Center, Danville

19107-5541

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia

15212-4772

Allegheny General Hospital, Pittsburgh

15213-3489

Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh

02886

Kent County Memorial Hospital, Warwick

79410-1894

Joe Arrington Cancer Research and Treatment Center, Lubbock

78284-7811

University of Texas Health Science Center at San Antonio, San Antonio

05405-0075

Vermont Cancer Center at University of Vermont, Burlington

23298-0037

MBCCOP - Massey Cancer Center, Richmond

98405-0986

CCOP - Northwest, Tacoma

25304-1297

David Lee Cancer Center at Charleston Area Medical Center, Charleston

54307-3508

St. Vincent Hospital, Green Bay

53211-2906

Oncology Alliance, S.C. - Milwaukee, Milwaukee

R3E 0V9

CancerCare Manitoba, Winnipeg

L5M 2N1

Carlo Fidani Peel Regional Cancer Centre at Credit Valley Hospital, Mississauga

H2L 4M1

Centre Hospitalier de l'Universite de Montreal, Montreal

H3A 1A1

Royal Victoria Hospital - Montreal, Montreal

H3G 1A4

Montreal General Hospital, Montreal

H3T 1E2

Jewish General Hospital - Montreal, Montreal

H3T 1M5

St. Mary's Hospital Center, Montreal

G1S 4L8

Hopital du Saint-Sacrement, Quebec, Québec

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NSABP Foundation Inc

NETWORK

NCT00004067 - Doxorubicin and Cyclophosphamide Plus Paclitaxel With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2 | Biotech Hunter | Biotech Hunter