Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma

PHASE3CompletedINTERVENTIONAL
Enrollment

253

Participants

Timeline

Start Date

September 30, 1999

Primary Completion Date

March 31, 2004

Study Completion Date

June 30, 2008

Conditions
Cardiac ToxicitySarcoma
Interventions
DRUG

cisplatin

DRUG

dexrazoxane hydrochloride

DRUG

doxorubicin hydrochloride

DRUG

etoposide

DRUG

ifosfamide

DRUG

methotrexate

PROCEDURE

conventional surgery

Trial Locations (148)

1211

Clinique de Pediatrie, Geneva

3052

Royal Children's Hospital, Parkville

6001

Princess Margaret Hospital for Children, Perth

10016

NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York

10021

Memorial Sloan-Kettering Cancer Center, New York

10029

Mount Sinai School of Medicine, New York

10032

Herbert Irving Comprehensive Cancer Center, New York

11042

Schneider Children's Hospital, New Hyde Park

13210

State University of New York - Upstate Medical University, Syracuse

14642

University of Rochester Cancer Center, Rochester

15213

Children's Hospital of Pittsburgh, Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

21201

Marlene & Stewart Greenebaum Cancer Center, University of Maryland, Baltimore

22908

Cancer Center at the University of Virginia, Charlottesville

24029

Carilion Roanoke Community Hospital, Roanoke

25304

West Virginia University Medical School-Charleston, Charleston

27710

Duke Comprehensive Cancer Center, Durham

28801

Mission Saint Joseph's Health System, Asheville

29605

Children's Hospital of Greenville Hospital System, Greenville

30322

Emory University Hospital - Atlanta, Atlanta

32207

Nemours Children's Clinic, Jacksonville

32803

Walt Disney Memorial Cancer Institute, Orlando

33136

Sylvester Cancer Center, University of Miami, Miami

33155

Miami Children's Hospital, Miami

33407

St. Mary's Hospital, West Palm Beach

33701

All Children's Hospital, St. Petersburg

36688

MBCCOP - Gulf Coast, Mobile

48201

Children's Hospital of Michigan, Detroit

48236

St. John's Hospital and Medical Center, Detroit

48503

Hurley Medical Center, Flint

53226

Midwest Children's Cancer Center, Milwaukee

55455

University of Minnesota Cancer Center, Minneapolis

55905

Mayo Clinic Cancer Center, Rochester

58102

Veterans Affairs Medical Center - Fargo, Fargo

58122

CCOP - Merit Care Hospital, Fargo

60453

Hope Children's Hospital, Oak Lawn

60612

Rush-Presbyterian-St. Luke's Medical Center, Chicago

60614

Children's Memorial Hospital, Chicago, Chicago

61602

CCOP - Illinois Oncology Research Association, Peoria

61637

Saint Jude Midwest Affiliate, Peoria

63104

Cardinal Glennon Children's Hospital, St Louis

63110

Washington University School of Medicine, St Louis

64108

Children's Mercy Hospital, Kansas City

65212

University of Missouri-Columbia Hospital and Clinics, Columbia

67214

Via Christi Regional Medical Center, Wichita

70112

MBCCOP - LSU Health Sciences Center, New Orleans

Tulane University School of Medicine, New Orleans

70121

CCOP - Ochsner, New Orleans

72205

University of Arkansas for Medical Sciences, Little Rock

74136

Natalie Warren Bryant Cancer Center, Tulsa

75230

Medical City Dallas Hospital, Dallas

76508

Scott and White Clinic, Temple

77030

Baylor College of Medicine, Houston

80218

Children's Hospital of Denver, Denver

85724

Arizona Cancer Center, Tucson

87131

University of New Mexico School of Medicine, Albuquerque

90806

Long Beach Memorial Medical Center, Long Beach

92120

Kaiser Permanente-Southern California Permanente Medical Group, San Diego

92868

Children's Hospital of Orange County, Orange

94304

Lucile Packard Children's Hospital at Stanford, Palo Alto

94535

David Grant Medical Center, Travis Air Force Base

95816

Sutter Cancer Center, Sacramento

95817

University of California Davis Medical Center, Sacramento

96813

Cancer Research Center of Hawaii, Honolulu

97213

CCOP - Columbia River Program, Portland

97227

Legacy Emanuel Hospital and Health Center, Portland

98105

Children's Hospital and Regional Medical Center - Seattle, Seattle

35294-3300

University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham

92093-0658

University of California San Diego Cancer Center, La Jolla

90027-0700

Children's Hospital Los Angeles, Los Angeles

90095-1781

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles

92123-4282

Children's Hospital and Health Center, San Diego

94143-0128

UCSF Cancer Center and Cancer Research Institute, San Francisco

95051-5386

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

06520-8028

Yale Comprehensive Cancer Center, New Haven

20010-2970

Children's National Medical Center, Washington D.C.

20307-5000

Walter Reed Army Medical Center, Washington D.C.

32610-100277

Shands Hospital and Clinics, University of Florida, Gainesville

33176-2197

Baptist Hospital of Miami, Miami

33682-7757

CCOP - Florida Pediatric, Tampa

96859-5000

Tripler Army Medical Center, Honolulu

60637-1470

University of Chicago Cancer Research Center, Chicago

46202-5289

Indiana University Cancer Center, Indianapolis

52242-1009

Holden Comprehensive Cancer Center at The University of Iowa, Iowa City

66160-7357

University of Kansas Medical Center, Kansas City

67214-3882

CCOP - Wichita, Wichita

04401

Eastern Maine Medical Center, Bangor

04101

Maine Children's Cancer Program, Portland

21231-2410

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

02111

Boston Floating Hospital Infants and Children, Boston

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana-Farber Cancer Institute, Boston

01655

University of Massachusetts Memorial Medical Center, Worcester

48109-0752

University of Michigan Comprehensive Cancer Center, Ann Arbor

49007-3731

CCOP - Kalamazoo, Kalamazoo

39216-4505

University of Mississippi Medical Center, Jackson

39534-2576

Keesler Medical Center - Keesler AFB, Keesler Air Force Base

68198-3330

University of Nebraska Medical Center, Omaha

03756-0002

Norris Cotton Cancer Center, Lebanon

07601

CCOP - Northern New Jersey, Hackensack

Hackensack University Medical Center, Hackensack

08901

Cancer Institute of New Jersey, New Brunswick

14263-0001

Roswell Park Cancer Institute, Buffalo

11790-7775

State University of New York Health Sciences Center - Stony Brook, Stony Brook

27599-7295

Lineberger Comprehensive Cancer Center, UNC, Chapel Hill

28232-2861

Carolinas Medical Center, Charlotte

28233-3549

Presbyterian Healthcare, Charlotte

27858-4354

East Carolina University School of Medicine, Greenville

27157-1082

Comprehensive Cancer Center at Wake Forest University, Winston-Salem

45229-3039

Children's Hospital Medical Center - Cincinnati, Cincinnati

44106-5065

Ireland Cancer Center, Cleveland

43205-2696

Children's Hospital of Columbus, Columbus

73126-0307

Oklahoma Memorial Hospital, Oklahoma City

97201-3098

Doernbecher Children's Hospital, Portland

19134-1095

St. Christopher's Hospital for Children, Philadelphia

29425-0721

Medical University of South Carolina, Charleston

37614-0622

James H. Quillen College of Medicine, Johnson City

38105-2794

Saint Jude Children's Research Hospital, Memphis

37232-6838

Vanderbilt-Ingram Cancer Center, Nashville

75230-2503

Texas Oncology P.A., Dallas

75235-9154

Simmons Cancer Center - Dallas, Dallas

77555-0209

University of Texas Medical Branch, Galveston

77030-4009

University of Texas - MD Anderson Cancer Center, Houston

78236-5300

San Antonio Military Pediatric Cancer and Blood Disorders Center, Lackland Air Force Base

78229-3900

MBCCOP - South Texas Pediatric, San Antonio

78284-7811

University of Texas Health Science Center at San Antonio, San Antonio

05401-3498

Vermont Cancer Center, Burlington

22042-3300

Inova Fairfax Hospital, Falls Church

23708-2197

Naval Medical Center, Portsmouth, Portsmouth

23298-0037

Massey Cancer Center, Richmond

98109-1024

Fred Hutchinson Cancer Research Center, Seattle

98431-5000

Madigan Army Medical Center, Tacoma

26506-9300

West Virginia University Hospitals, Morgantown

54307-3508

St. Vincent Hospital, Green Bay

53792-6164

University of Wisconsin Comprehensive Cancer Center, Madison

T2T 5C7

Alberta Children's Hospital, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

V6H 3V4

British Columbia Children's Hospital, Vancouver

B3J 3G9

IWK Health Centre, Halifax

L8N 3Z5

Children's Hospital, Hamilton

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

McGill University Health Center - Montreal Children's Hospital, Montreal

H3T 1C5

Hopital Sainte Justine, Montreal

GIV 4G2

Centre Hospitalier de L'Universite Laval, Sainte-Foy

9713 EZ

Academisch Ziekenhuis Groningen, Groningen

00912

San Jorge Childrens Hospital, Santurce

CH 3010

Swiss Pediatric Oncology Group Bern, Bern

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK