Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes

PHASE3CompletedINTERVENTIONAL
Enrollment

5,351

Participants

Timeline

Start Date

March 31, 1999

Primary Completion Date

December 31, 2008

Study Completion Date

December 31, 2012

Conditions
Breast Cancer
Interventions
DRUG

cyclophosphamide

Arm 1: 600 mg/m2 IV every 21 days for 4 cycles; Arm 3: 500 mg/m2 IV every 21 days for 4 cycles

DRUG

docetaxel

Arm 1: 100 mg/m2 IV every 21 days for 4 cycles; Arms 2 and 3: 75 mg/m2 IV every 21 days for 4 cycles

DRUG

doxorubicin

Arm 1: 60 mg/m2 IV every 21 days for 4 cycles; Arms 2 and 3: 50 mg/m2 IV every 21 days for 4 cycles

Trial Locations (157)

10305

Staten Island University Hospital, Staten Island

10451

Lincoln Medical and Mental Health Center, The Bronx

10466

MBCCOP-Our Lady of Mercy Cancer Center, The Bronx

12208

New York Oncology Hematology, P.C. - Albany Regional Cancer Center, Albany

12801

Charles R. Wood Foundation Cancer Center at Glens Falls Hospital, Glens Falls

13217

CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse

17315

Wellspan Health - York Cancer Center, York

18103

John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown

18501

Mercy Hospital Cancer Center - Scranton, Scranton

19096

CCOP - MainLine Health, Wynnewood

19141

Albert Einstein Cancer Center, Philadelphia

19899

CCOP - Christiana Care Health Services, Wilmington

20060

MBCCOP - Howard University Cancer Center, Washington D.C.

21237

Franklin Square Hospital Center, Baltimore

23507

Eastern Virginia Medical School, Norfolk

23606

Virginia Oncology Associates - Newport News, Newport News

24014

Oncology and Hematology Associates of Southwest Virginia, Inc., Roanoke

26102

Camden-Clark Memorial Hospital, Parkersburg

27216

Alamance Cancer Center, Burlington

29303

CCOP - Upstate Carolina, Spartanburg

29615

CCOP - Greenville, Greenville

30322

Winship Cancer Institute of Emory University, Atlanta

32114

Halifax Medical Center, Daytona Beach

32207

Baptist Regional Cancer Institute - Jacksonville, Jacksonville

32806

MD Anderson Cancer Center Orlando, Orlando

33136

University of Miami Sylvester Cancer Center, Miami

33140

CCOP - Mount Sinai Medical Center, Miami Beach

33756

Morton Plant Hospital, Clearwater

34239

Sarasota Memorial Hospital, Sarasota

35801

Comprehensive Cancer Institute, Huntsville

37916

Thompson Cancer Survival Center, Knoxville

38146

Baptist Cancer Institute - Memphis at Baptist Memorial Hospital - Memphis, Memphis

40207

Consultants in Blood Disorders and Cancer, Louisville

43206

CCOP - Columbus, Columbus

44122

South Pointe Hospital - Cancer Care Center, Warrensville Heights

44309

Akron City Hospital, Akron

44710

Aultman Hospital Cancer Center at Aultman Health Foundation, Canton

45236

Jewish Hospital of Cincinnati, Incorporated, Cincinnati

45429

CCOP - Dayton, Kettering

46260

St. Vincent Hospital and Health Care Center, Indianapolis

46321

Community Hospital, Munster

48106

CCOP - Michigan Cancer Research Consortium, Ann Arbor

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

48824

Michigan State University, East Lansing

49503

CCOP - Grand Rapids, Grand Rapids

52804

Genesis Medical Center, Davenport

53215

St. Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin Cancer Center, Milwaukee

54301

CCOP - St. Vincent Hospital Cancer Center, Green Bay, Green Bay

54449

CCOP - Marshfield Clinic Research Foundation, Marshfield

55415

Hennepin County Medical Center - Minneapolis, Minneapolis

55416

CCOP - Metro-Minnesota, Saint Louis Park

55805

CCOP - Duluth, Duluth

58122

CCOP - Merit Care Hospital, Fargo

59101

CCOP - Montana Cancer Consortium, Billings

60201

CCOP - Evanston, Evanston

60612

Rush-Presbyterian-St. Luke's Medical Center, Chicago

60657

Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago

61602

CCOP - Illinois Oncology Research Association, Peoria

61801

CCOP - Carle Cancer Center, Urbana

62526

CCOP - Central Illinois, Decatur

63141

CCOP - St. Louis-Cape Girardeau, St Louis

64131

CCOP - Kansas City, Kansas City

65203

Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia

65807

CCOP - Cancer Research for the Ozarks, Springfield

68114

Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha

68131

CCOP - Missouri Valley Cancer Consortium, Omaha

70112

Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans, New Orleans

Tulane University Medical Center, New Orleans

70121

CCOP - Ochsner, New Orleans

74136

CCOP - Oklahoma, Tulsa

75230

Medical City Dallas Hospital, Dallas

76508

CCOP - Scott and White Hospital, Temple

77030

Baylor College of Medicine, Houston

80010

University of Colorado Cancer Center at University of Colorado Health Sciences Center, Denver

83814

North Idaho Cancer Center, Coeur d'Alene

84604

Utah Valley Regional Medical Center - Provo, Provo

87131

MBCCOP - University of New Mexico HSC, Albuquerque

89106

CCOP - Southern Nevada Cancer Research Foundation, Las Vegas

90813

Pacific Shores Medical Group, Long Beach

92037

Scripps Cancer Center at Scripps Clinic, La Jolla

92120

Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego

92262

Comprehensive Cancer Centers of the Desert, Palm Springs

92354

Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda

92868

Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center, Orange

93720

California Cancer Center, Fresno

94589

Kaiser Permanente Medical Center - Vallejo, Vallejo

94904

Sutter Health Western Division Cancer Research Group, Greenbrae

95403

CCOP - Santa Rosa Memorial Hospital, Santa Rosa

95816

Sutter Cancer Center, Sacramento

96813

Cancer Research Center of Hawaii, Honolulu

97213

CCOP - Columbia River Oncology Program, Portland

98101

CCOP - Virginia Mason Research Center, Seattle

98109

Puget Sound Oncology Consortium, Seattle

99519-6604

Providence Alaska Medical Center, Anchorage

85006-2726

CCOP - Western Regional, Arizona, Phoenix

91010-3000

City of Hope Comprehensive Cancer Center, Duarte

92093-0658

Rebecca and John Moores UCSD Cancer Center, La Jolla

94609-3305

CCOP - Bay Area Tumor Institute, Oakland

94305-5408

Stanford Cancer Center at Stanford University Medical Center, Palo Alto

94107-1728

Catholic Healthcare West - Westbay Region, San Francisco

80209-5031

CCOP - Colorado Cancer Research Program, Incorporated, Denver

06360-7106

University of Connecticut Cancer Center at University of Connecticut Health Center, Farmington

06102-5037

Hartford Hospital, Hartford

30342-1701

CCOP - Atlanta Regional, Atlanta

30912-4000

Medical College of Georgia Comprehensive Cancer Center, Augusta

30905-5650

Dwight David Eisenhower Army Medical Center, Fort Gordon

60612-9985

John H. Stroger, Jr. Hospital of Cook County, Chicago

46206-1367

Methodist Cancer Center at Methodist Hospital, Indianapolis

50309-1016

CCOP - Iowa Oncology Research Association, Des Moines

52242-1009

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

67214-3882

CCOP - Wichita, Wichita

40536-0093

Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington

40202-5070

Norton Healthcare Cancer Center, Louisville

04401

Eastern Maine Medical Center, Bangor

20889-5000

National Naval Medical Center, Bethesda

02118

Cancer Research Center at Boston Medical Center, Boston

01805

Lahey Clinic Medical Center - Burlington, Burlington

01201

Berkshire Medical Center, Pittsfield

01199

Baystate Medical Center, Springfield

49007-3731

CCOP - Kalamazoo, Kalamazoo

48073-6769

CCOP - Beaumont, Royal Oak

48075-9975

Providence Cancer Institute at Providence Hospital, Southfield

63110-0250

St. Louis University Hospital Cancer Center, St Louis

07601

CCOP - Northern New Jersey, Hackensack

08903

Cancer Institute of New Jersey, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

27858-4354

Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina, Greenville

27104-4241

CCOP - Southeast Cancer Control Consortium, Winston-Salem

27157-1082

Comprehensive Cancer Center at Wake Forest University, Winston-Salem

45267-0502

Charles M. Barrett Cancer Center at University Hospital, Cincinnati

43210-1240

Arthur G. James Cancer Hospital - Ohio State University, Columbus

43623-3456

CCOP - Toledo Community Hospital, Toledo

17822-2001

Geisinger Medical Center, Danville

19107-5541

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia

15212-4772

Allegheny General Hospital, Pittsburgh

15213-3489

Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh

19612-6052

Reading Hospital and Medical Center, Reading

75235-9154

Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas

79410-1894

Joe Arrington Cancer Research and Treatment Center, Lubbock

78284-7811

University of Texas Health Science Center at San Antonio, San Antonio

05201

Green Mountain Oncology Group, Bennington

23298-0037

MBCCOP - Massey Cancer Center, Richmond

98405-0986

CCOP - Northwest, Tacoma

25304-1297

Charleston Area Medical Center, Charleston

T2N 4N2

Tom Baker Cancer Center - Calgary, Calgary

R3E 0V9

CancerCare Manitoba, Winnipeg

L5M 2N1

Credit Valley Hospital, Mississauga

K1H 1C4

Ottawa Regional Cancer Centre, Ottawa

M5B 1W8

St. Michael's Hospital - Toronto, Toronto

H2L-4M1

Centre Hospitalier de l'Universite de Montreal, Montreal

H3A 1A1

Royal Victoria Hospital - Montreal, Montreal

H3G 1A4

Montreal General Hospital, Montreal

H3T 1E2

Jewish General Hospital - Montreal, Montreal

H3T 1M5

St. Mary's Hospital Center, Montreal

G1S 4L8

Hopital du Saint-Sacrement, Quebec, Québec

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NSABP Foundation Inc

NETWORK