NCT00002931View on ClinicalTrials.gov

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

February 28, 1997

Primary Completion Date

December 31, 2014

Study Completion Date

December 31, 2014

Conditions
Brain and Central Nervous System TumorsExtragonadal Germ Cell TumorOvarian CancerTeratomaTesticular Germ Cell Tumor
Interventions
BIOLOGICAL

filgrastim

5 ug/kg bid beginning 4 days prior to and continuing through stem cell collection.

DRUG

carboplatin

AUC=7, daily X 3

DRUG

etoposide

20 mg/kg by 2 hours infusion daily X 3

DRUG

ifosfamide

3 gm/m2 IV over 30 minutes X 3 days

DRUG

paclitaxel

425 mg/m2 as 24 hour continuous infusion

PROCEDURE

autologous bone marrow transplantation

Given in two divided infusions on day -2 and day 0

PROCEDURE

bone marrow ablation with stem cell support

Two cycles of high dose chemotherapy followed by stem cell reinfusion

Trial Locations (1)

91010-3000

City of Hope Comprehensive Cancer Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER

NCT00002931 - Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer | Biotech Hunter | Biotech Hunter