Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

September 30, 1994

Primary Completion Date

May 31, 2014

Study Completion Date

May 31, 2014

Conditions
Colorectal CancerMetastatic Cancer
Interventions
DRUG

floxuridine

Starting dose of 0.2 mg/kg/day for 14 consecutive days.

DRUG

fluorouracil

300 mg/m2/day by intravenous bolus 24 hours apart for 5 consecutive days.

DRUG

leucovorin calcium

500 mg/m2/day by continuous intravenous infusion beginning 24 hours prior to the first dose of 5-FU and continuing until 12 hours following the last dose of 5-FU.

PROCEDURE

adjuvant therapy

Chemotherapy given after hepatic resection

PROCEDURE

conventional surgery

Hepatic resection

Trial Locations (1)

91010-3000

City of Hope Comprehensive Cancer Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER