53
Participants
Start Date
October 31, 1994
Primary Completion Date
April 30, 2002
Study Completion Date
April 30, 2002
Filgrastim
Donors receive Filgrastim SC (Subcutaneously) every 12 hours for 2 days prior to stem cell collection.
Cladribine
Continuous infusion for 5 days, beginning 4 hours before Ara-C first dose.
Cyclosporine
For GVHD prophylaxis, cyclosporine via continuous IV infusion. Oral cyclosporine administered once tolerating oral feeding and continued for 6 months postinfusion. Then dose tapered 10% weekly until discontinued.
Cytarabine (Ara-C)
Group 1A: Ara-C IV over 2 hours on days -7, -6, -5, -4 and -3; Group 1B: Ara-C IV begins 4 hours after fludarabine infusion, continues for 4 hours.
Fludarabine Phosphate
IV over 30 minutes daily on days -6, -5, -4 and -3.
Idarubicin
IV Days -6, -5 and -4.
Methylprednisolone
Begins 5 days after infusion and is gradually tapered.
Peripheral Blood Stem Cell Transplantation
Cell infusion Day 0.
University of Texas - MD Anderson Cancer Center, Houston
National Cancer Institute (NCI)
NIH
M.D. Anderson Cancer Center
OTHER