Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous or Acute Leukemia

Subcutaneously (SQ) daily every 12 hours starting 2-4 days prior to the first stem cell collection and before DAC infusion.

Administered orally every 6 hours on consecutive days -6 through -4.

Given intravenously (IV) over 1 hour on consecutive days -3 and -2.

Patients intolerant to tacrolimus receive cyclosporine IV beginning on day -2, then orally following tolerance and engraftment.

IV over 4 hours on days -8 and -7.

Given intrathecally or intraventricularly monthly, beginning on the second month through the eighth month of treatment.

Given according to clinical grade of GVHD procedures.

IV beginning one day before stem cell infusion, then orally following tolerance to tacrolimus.

Infusion of stem cells on Day 0.

Stem cell infusion on Day 0.