51
Participants
Start Date
June 30, 1996
Primary Completion Date
February 28, 2003
Study Completion Date
March 31, 2009
filgrastim
10 microgram/kg body wt subcutaneously daily beginning on d 14 and con't until peripheral blood collection is completed
busulfan
1 mg/kg PO q 6 hrs for 16 doses on days -7 thru -4.
cytarabine
2000 mg/ sq meter IV over 2 hours q 12 hrs x 8 doses on days 1-4
etoposide
40 mg/kg (total dose) IV cont infusion over 96 hrs on days 1-4 of consolidation therapy and 60 mg/kg IV over 4 hrs on day -3 of transplant
methotrexate
For patients with documented CNS disease at first relapse, 12 mg intrathecal for a total of 6 doses given before and/or after transplantation
peripheral blood stem cell transplantation
Infusion on Day 0
Marlene & Stewart Greenebaum Cancer Center, University of Maryland, Baltimore
UCSF Cancer Center and Cancer Research Institute, San Francisco
St. Joseph's Hospital and Medical Center, Paterson
National Cancer Institute (NCI)
NIH
Alliance for Clinical Trials in Oncology
OTHER