Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

September 30, 1994

Primary Completion Date

September 30, 2003

Study Completion Date

March 31, 2007

Conditions
Brain TumorCentral Nervous System Tumor
Interventions
BIOLOGICAL

Sargramostim

Given IV

DRUG

cyclophosphamide

Given IV

DRUG

melphalan

Given IV

PROCEDURE

autologous bone marrow transplantation

PROCEDURE

bone marrow ablation with stem cell support

PROCEDURE

peripheral blood stem cell transplantation

Trial Locations (118)

2145

Children's Hospital at Westmead, Westmead

3052

Royal Children's Hospital, Parkville

4029

Royal Children's Hospital, Brisbane

10029

Mount Sinai School of Medicine, New York

10128

Beth Israel Hospital North, New York

11042

Schneider Children's Hospital, New Hyde Park

13210

State University of New York - Upstate Medical University, Syracuse

14642

James P. Wilmot Cancer Center, Rochester

22908

Cancer Center at the University of Virginia, Charlottesville

24029

Carilion Medical Center for Children, Roanoke

25302

West Virginia University - Charleston, Charleston

27710

Duke Comprehensive Cancer Center, Durham

28233

Presbyterian Healthcare, Charlotte

28801

Mission St. Joseph's Health System, Asheville

29605

Children's Hospital of Greenville Hospital System, Greenville

30342

Children's Healthcare of Atlanta - Scottish Rite, Atlanta

32207

Nemours Children's Clinic, Jacksonville

32504

Sacred Heart Children's Hospital, Pensacola

32804

Florida Hospital Cancer Institute, Orlando

32806

Nemours Children's Clinic-Orlando, Orlando

33021

Joe DiMaggio Children's Hospital at Memorial, Hollywood

33136

Sylvester Cancer Center, University of Miami, Miami

33316

Broward General Medical Center, Fort Lauderdale

33407

St. Mary's Hospital, West Palm Beach

33701

All Children's Hospital, St. Petersburg

33908

Children's Hospital of Southwest Florida, Fort Myers

35233

University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham

36604

University of South Alabama Medical Center, Mobile

37604

East Tennessee State University Cancer Center at JCMC, Johnson City

48201

Children's Hospital of Michigan, Detroit

48236

St. John Hospital and Medical Center, Detroit

48503

Hurley Medical Center, Flint

53226

Midwest Children's Cancer Center, Milwaukee

60453

Advocate Hope Children's Hospital, Oak Lawn

60612

Rush-Presbyterian-St. Luke's Medical Center, Chicago

60614

Children's Memorial Hospital - Chicago, Chicago

61637

Saint Jude Midwest Affiliate, Peoria

63104

Cardinal Glennon Children's Hospital, St Louis

63105

Washington University Medical Center, St Louis

65212

University of Missouri-Columbia Hospital and Clinics, Columbia

67214

Via Christi Regional Medical Center, Wichita

Wesley Medical Center, Wichita

70112

MBCCOP - LSU Health Sciences Center, New Orleans

Tulane University School of Medicine, New Orleans

70118

Children's Hospital of New Orleans, New Orleans

70121

Ochsner Clinic Foundation, New Orleans

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74136

Warren Clinic, Tulsa

75230

Medical City Dallas Hospital, Dallas

76104

Cook Children's Medical Center - Fort Worth, Fort Worth

76508

Scott and White Memorial Hospital, Temple

78207

University of Texas Health Science Center at San Antonio, San Antonio

78236

San Antonio Military Pediatric Cancer and Blood Disorders Center, Lackland Air Force Base

78466

Driscoll Children's Hospital, Corpus Christi

85724

Arizona Cancer Center, Tucson

87131

University of New Mexico Cancer Research and Treatment Center, Albuquerque

92120

Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego

95816

Sutter Cancer Center, Sacramento

95817

University of California Davis Cancer Center, Sacramento

96813

Cancer Research Center of Hawaii, Honolulu

97227

Legacy Emanuel Hospital and Health Center, Portland

92093-0658

Rebecca and John Moores UCSD Cancer Center, La Jolla

92123-4282

Children's Hospital San Diego, San Diego

95051-5386

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

94305-5208

Stanford University Medical Center, Stanford

06520-8028

Yale Comprehensive Cancer Center, New Haven

20307-5000

Walter Reed Army Medical Center, Washington D.C.

32610-100277

Shands Hospital and Clinics, University of Florida, Gainesville

33155-4069

Miami Children's Hospital, Miami

33176-2197

Baptist Hospital of Miami, Miami

33677-4227

Tampa Children's Hospital, Tampa

96859-5000

Tripler Army Medical Center, Honolulu

66160-7357

University of Kansas Medical Center, Kansas City

67214-3882

CCOP - Wichita, Wichita

04401

Eastern Maine Medical Center, Bangor

04074-9308

Maine Children's Cancer Program, Scarborough

21201-1595

Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore

21231-2410

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

02111

Floating Hospital for Children, Boston

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

01655

University of Massachusetts Memorial Medical Center - University Campus, Worcester

39216-4505

University of Mississippi Medical Center, Jackson

39534-2511

Keesler Medical Center - Keesler AFB, Keesler Air Force Base

03756-0002

Norris Cotton Cancer Center, Lebanon

07601

Hackensack University Medical Center, Hackensack

14263-0001

Roswell Park Cancer Institute, Buffalo

11790-7775

State University of New York Health Sciences Center - Stony Brook, Stony Brook

28232-2861

Carolinas Medical Center, Charlotte

27858-4354

East Carolina University School of Medicine, Greenville

27157-1081

Comprehensive Cancer Center at Wake Forest University, Winston-Salem

19134-1095

St. Christopher's Hospital for Children, Philadelphia

02818

Rhode Island Hospital, Providence

29425-0721

Medical University of South Carolina, Charleston

38105-2794

St. Jude Children's Research Hospital, Memphis

75235-9154

Simmons Cancer Center - Dallas, Dallas

77555-0361

University of Texas Medical Branch, Galveston

77030-2399

Texas Children's Cancer Center, Houston

05401-3498

Vermont Cancer Center, Burlington

22042-3300

Inova Fairfax Hospital, Falls Church

23708-5100

Naval Medical Center, Portsmouth, Portsmouth

23298-0037

Massey Cancer Center, Richmond

98431-5000

Madigan Army Medical Center, Tacoma

26506-9300

West Virginia University Hospitals, Morgantown

54307-9070

St. Vincent Hospital, Green Bay

T2T 5C7

Alberta Children's Hospital, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

L8N 3Z5

Chedoke-McMaster Hospitals, Hamilton

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

Hospital for Sick Children, Toronto

H3G 1A4

McGill University Health Center - Montreal Children's Hospital, Montreal

H3T 1C5

Hopital Sainte Justine, Montreal

GIV 4G2

Centre de Recherche du Centre Hospitalier de l'Universite Laval, Sainte-Foy

9700 RB

Academisch Ziekenhuis Groningen, Groningen

00912

San Jorge Childrens Hospital, Santurce

CH 3010

Swiss Pediatric Oncology Group Bern, Bern

CH 1211

Swiss Pediatric Oncology Group Geneva, Geneva

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK