NCT00001322View on ClinicalTrials.gov

The Effects of Reproductive Hormones on Mood and Behavior

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

June 9, 1994

Primary Completion Date

March 3, 2020

Study Completion Date

March 3, 2020

Conditions
Healthy Volunteers
Interventions
DRUG

Leuprolide Acetate 3.75

Eight to 12 weeks of GnRH agonist, Leuprolide Acetate 3.75 mg given intramuscularly monthly

DRUG

Estradiol

Transdermal Estradiol, 100mcg/day by skin patch

DRUG

Progesterone

Progesterone suppository, 200mg vaginally twice/day

DRUG

Placebo suppository

Placebo suppository twice daily

DRUG

Placebo patch

Placebo by skin patch

Trial Locations (1)

20892

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda

All Listed Sponsors
lead

National Institute of Mental Health (NIMH)

NIH