A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDRTB) in HIV-Infected Patients.

NACompletedINTERVENTIONAL
Enrollment

525

Participants

Timeline

Start Date

Not specified

Study Completion Date

October 31, 1998

Conditions
HIV InfectionsTuberculosis
Interventions
DRUG

Cycloserine

DRUG

Ethionamide

DRUG

Capreomycin sulfate

DRUG

Aminosalicylic acid

DRUG

Streptomycin sulfate

DRUG

Ethambutol hydrochloride

DRUG

Amikacin sulfate

DRUG

Isoniazid

DRUG

Pyrazinamide

DRUG

Pyridoxine hydrochloride

DRUG

Levofloxacin

DRUG

Rifampin

DRUG

Clofazimine

Trial Locations (21)

10003

Beth Israel Med Ctr, New York

10011

Clinical Directors Network of Region II, New York

10016

Bellevue Hosp / New York Univ Med Ctr, New York

10019

Saint Clare's Hosp and Health Ctr, New York

10021

Cornell Univ Med Ctr, New York

10029

Mount Sinai Med Ctr, New York

10037

Harlem AIDS Treatment Group / Harlem Hosp Ctr, New York

10456

Bronx Lebanon Hosp Ctr, The Bronx

10461

Bronx Municipal Hosp Ctr/Jacobi Med Ctr, The Bronx

Comprehensive Health Care Ctr / Bronx Municipal Hosp, The Bronx

Montefiore Drug Treatment Ctr / Bronx Municipal Hosp, The Bronx

Montefiore Family Health Ctr / Bronx Municipal Hosp, The Bronx

Samaritan Village Inc / Bronx Municipal Hosp, The Bronx

10465

Jack Weiler Hosp / Bronx Municipal Hosp, The Bronx

10467

Montefiore Med Ctr / Bronx Municipal Hosp, The Bronx

North Central Bronx Hosp / Bronx Municipal Hosp, The Bronx

48202

Henry Ford Hosp, Detroit

60612

Cook County Hosp, Chicago

100323784

Columbia Presbyterian Med Ctr, New York

112032098

Interfaith Med Ctr, Brooklyn

SUNY / Health Sciences Ctr at Brooklyn, Brooklyn

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH