A Phase III Randomized Trial of Low-Dose Versus Standard-Dose mBACOD Chemotherapy With rGM-CSF for Treatment of AIDS-Associated Non-Hodgkin's Lymphoma

PHASE3CompletedINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

Not specified

Study Completion Date

February 29, 1996

Conditions
Lymphoma, Non-HodgkinHIV Infections
Interventions
DRUG

Bleomycin sulfate

DRUG

Vincristine sulfate

DRUG

Doxorubicin hydrochloride

DRUG

Cyclophosphamide

DRUG

Allopurinol

DRUG

Methotrexate

DRUG

Cytarabine

DRUG

Leucovorin calcium

DRUG

Sargramostim

DRUG

Dexamethasone

Trial Locations (22)

10016

NY Univ. HIV/AIDS CRS, New York

10021

Memorial Sloan-Kettering Cancer Ctr., New York

14215

SUNY - Buffalo, Erie County Medical Ctr., Buffalo

14642

Univ. of Rochester ACTG CRS, Rochester

15213

Pitt CRS, Pittsburgh

19104

Hosp. of the Univ. of Pennsylvania CRS, Philadelphia

60611

Northwestern University CRS, Chicago

60612

Rush Univ. Med. Ctr. ACTG CRS, Chicago

80262

University of Colorado Hospital CRS, Aurora

90095

UCLA CARE Center CRS, Los Angeles

275997215

Unc Aids Crs, Chapel Hill

432101228

The Ohio State Univ. AIDS CRS, Columbus

462025250

Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis

900331079

USC CRS, Los Angeles

941102859

Ucsf Aids Crs, San Francisco

Unknown

Johns Hopkins Adult AIDS CRS, Baltimore

Bmc Actg Crs, Boston

Washington U CRS, St Louis

Case CRS, Cleveland

02118

Beth Israel Deaconess Med. Ctr., ACTG CRS, Boston

02215

Beth Israel Deaconess - East Campus A0102 CRS, Boston

Beth Israel Med. Ctr. (Mt. Sinai), New York

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Schering-Plough

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH