A Randomized, Double-Blind Phase II/III Trial of Monotherapy vs. Combination Therapy With Nucleoside Analogs in HIV-Infected Persons With CD4 Cells of 200-500/mm3

PHASE2CompletedINTERVENTIONAL
Enrollment

2,100

Participants

Timeline

Start Date

Not specified

Study Completion Date

November 30, 1995

Conditions
HIV Infections
Interventions
DRUG

Zidovudine

DRUG

Zalcitabine

DRUG

Didanosine

Trial Locations (58)

10003

Beth Israel Med. Ctr. (Mt. Sinai), New York

10016

NY Univ. HIV/AIDS CRS, New York

10021

Cornell University A2201, New York

Memorial Sloan-Kettering Cancer Ctr., New York

14215

SUNY - Buffalo, Erie County Medical Ctr., Buffalo

14642

Univ. of Rochester ACTG CRS, Rochester

19104

Hosp. of the Univ. of Pennsylvania CRS, Philadelphia

20059

Howard University Hosp., Div. of Infectious Diseases, ACTU, Washington D.C.

21287

Johns Hopkins Adult AIDS CRS, Baltimore

27401

Regional Center for Infectious Disease, Wendover Medical Center CRS, Greensboro

27599

Unc Aids Crs, Chapel Hill

27610

Wake County Health and Human Services CRS, Raleigh

27710

Duke Univ. Med. Ctr. Adult CRS, Durham

28203

Carolinas HealthCare System, Carolinas Med. Ctr., Charlotte

30365

Emory Univ. Hemophilia Program Office, Atlanta

33136

Univ. of Miami AIDS CRS, Miami

35294

Alabama Therapeutics CRS, Birmingham

43210

The Ohio State Univ. AIDS CRS, Columbus

44106

Case CRS, Cleveland

45267

Univ. of Cincinnati CRS, Cincinnati

46202

Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis

Methodist Hosp. of Indiana, Indianapolis

52242

Univ. of Iowa Healthcare, Div. of Infectious Diseases, Iowa City

55455

Hennepin County Med. Ctr., Div. of Infectious Diseases, Minneapolis

60611

Northwestern University CRS, Chicago

60612

Cook County Hosp. CORE Ctr., Chicago

Rush Univ. Med. Ctr. ACTG CRS, Chicago

63112

St. Louis ConnectCare, Infectious Diseases Clinic, St Louis

70112

Tulane Hemophilia Treatment Ctr., New Orleans

Tulane Med. Ctr. - Charity Hosp. of New Orleans, ACTU, New Orleans

Tulane/LSU Maternal/Child CRS, New Orleans

80262

University of Colorado Hospital CRS, Aurora

90033

USC CRS, Los Angeles

90095

UCLA CARE Center CRS, Los Angeles

90502

Harbor-UCLA Med. Ctr. CRS, Torrance

92093

UCSD Maternal, Child, and Adolescent HIV CRS, San Diego

94305

Stanford CRS, Palo Alto

San Mateo County AIDS Program, San Mateo

94609

Children's Hosp. & Research Ctr. Oakland, Ped. Clinical Research Ctr. & Research Lab., Oakland

95128

Santa Clara Valley Med. Ctr., San Jose

96816

Univ. of Hawaii at Manoa, Leahi Hosp., Honolulu

98122

University of Washington AIDS CRS, Seattle

Unknown

Ucsd, Avrc Crs, San Diego

Ucsf Aids Crs, San Francisco

University of Minnesota, ACTU, Minneapolis

Washington U CRS, St Louis

Univ. of Nebraska Med. Ctr., Durham Outpatient Ctr., Omaha

NJ Med. School CRS, Newark

NYU Med. Ctr., Dept. of Medicine, New York

MetroHealth CRS, Cleveland

Puerto Rico-AIDS CRS, San Juan

Mbeya Med. Research Program, Mbeya Referral Hosp. CRS, Mbeya

02114

Massachusetts General Hospital ACTG CRS, Boston

02115

Brigham and Women's Hosp., Div. of Infectious Disease, Boston

HMS - Children's Hosp. Boston, Div. of Infectious Diseases, Boston

02118

Bmc Actg Crs, Boston

02215

Beth Israel Deaconess - East Campus A0102 CRS, Boston

Beth Israel Deaconess Med. Ctr., ACTG CRS, Boston

Sponsors
All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Glaxo Wellcome

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT00000625 - A Randomized, Double-Blind Phase II/III Trial of Monotherapy vs. Combination Therapy With Nucleoside Analogs in HIV-Infected Persons With CD4 Cells of 200-500/mm3 | Biotech Hunter | Biotech Hunter