Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone

After an initial 21 day balance study to demonstrate that a selected dose of PIH produced sufficient iron excretion, patients were begun on chronic therapy. PIH or placebo were given on days 4 to 9 and days 13 to 18 in a randomized, double-blind, cross-over design.

Placebo given at same time points as the Intervetnion for each clinical condition.