Antibody Therapies for Oncology
Total Trials
29
As Lead Sponsor
15
As Collaborator
14
Total Enrollment
1,675
NCT00089245
Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer
Phase: Phase 1
Role: Lead Sponsor
Start: Feb 5, 2004
Completion: Feb 2, 2022
NCT00911560
Bivalent Vaccine With Escalating Doses of the Immunological Adjuvant OPT-821, in Combination With Oral β-glucan for High-Risk Neuroblastoma
Phase: Phase 1/2
Role: Collaborator
Start: May 27, 2009
Completion: May 31, 2026
NCT01099644
Intraperitoneal RIT With 131I-8H9 for Pts With DSRCT and Other Solid Tumors Involving the Peritoneum
Start: Apr 30, 2010
Completion: Jun 11, 2019
NCT01419834
Humanized 3F8 Monoclonal Antibody (Hu3F8) in Patients With High-Risk Neuroblastoma and GD2-Positive Tumors
Start: Aug 15, 2011
Completion: Aug 2, 2023
NCT01502917
Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy
Start: Dec 31, 2011
Completion: Jan 31, 2022
NCT01757626
Combination Therapy of Antibody Hu3F8 With Granulocyte- Macrophage Colony Stimulating Factor (GM-CSF) in Patients With Relapsed/Refractory High-Risk Neuroblastoma
Start: Dec 31, 2012
Completion: Dec 31, 2025
NCT02307630
PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study
Phase: N/A
Start: Nov 30, 2014
Completion: Nov 30, 2025
NCT02502786
Humanized Monoclonal Antibody 3F8 (Hu3F8) With Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in the Treatment of Recurrent Osteosarcoma
Phase: Phase 2
Start: Jul 31, 2015
Completion: Jul 31, 2026
NCT02650648
Humanized Anti-GD2 Antibody Hu3F8 and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma
Start: Jan 5, 2016
Completion: Jul 28, 2025
NCT03033303
A Study of the Effect of Hu3F8/GM-CSF Immunotherapy Plus Isotretinoin in Patients in First Remission of High-Risk Neuroblastoma
Start: Jan 23, 2017
Completion: Sep 29, 2025
NCT03189706
Study of Chemoimmunotherapy for High-Risk Neuroblastoma
Phase: Early Phase 1
Start: Jun 12, 2017
Completion: Jun 30, 2026
NCT03363373
Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow
Start: Apr 3, 2018
Completion: Apr 30, 2028
NCT03275402
131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases
Phase: Phase 2/3
Start: Dec 11, 2018
Completion: Jun 2, 2023
NCT03860207
Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3F8-BsAb) in Patients With Relapsed/Refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers
Start: Feb 22, 2019
Completion: Oct 20, 2021
NCT04022213
A Study of the Drug I131-Omburtamab in People With Desmoplastic Small Round Cell Tumors and Other Solid Tumors in the Peritoneum
Start: Jul 15, 2019
NCT04750239
Safety and Clinical Activity of Nivatrotamab in Relapsed/Recurrent Metastatic Small-cell Lung Cancer
Start: Aug 17, 2021
Completion: Apr 8, 2022
NCT04167618
177Lu-DTPA-Omburtamab Radioimmunotherapy for Recurrent or Refractory Medulloblastoma
Start: Sep 30, 2021
Completion: Aug 11, 2022
NCT04560166
Naxitamab and GM-CSF in Combination With IT in Patients With High-Risk Neuroblastoma
Start: Nov 8, 2021
Completion: Sep 21, 2022
NCT04909515
Naxitamab and Granulocyte-Macrophage Colony Stimulating Factor (GMCSF) and Isotretinoin for Consolidation of Patients With High-Risk Neuroblastoma in First Remission.
Start: Dec 2, 2021
Completion: Apr 30, 2027
NCT05063357
131I-omburtamab Delivered by Convection-Enhanced Delivery in Patients With Diffuse Intrinsic Pontine Glioma
Start: Mar 31, 2022
Completion: Dec 31, 2026
NCT04743661
131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma
Start: Apr 4, 2022
Completion: Oct 30, 2030
NCT05077423
A Phase 1 Trial of CD33xCD3 BsAb in Pediatric Patients With Relapsed or Refractory Acute Myeloid Leukemia
Start: May 25, 2022
Completion: Dec 1, 2022
NCT04315246
177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma)
Start: Aug 31, 2022
Completion: Dec 31, 2024
NCT05489887
Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma
Start: Sep 14, 2022
Completion: Sep 30, 2036
NCT05130255
GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2
Start: Nov 17, 2022
NCT05994157
Phase 1, Open-label, Dose-escalation Trial with CD38-SADA:177 Lu-DOTA Drug Complex in Subjects with Relapsed or Refractory Non-Hodgkin Lymphoma
Start: Feb 28, 2025
Completion: Jan 31, 2028
NCT07027748
Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma
Start: Jun 27, 2025
Completion: Dec 1, 2027
NCT07011654
Study of Naxitamab and Sacituzumab Govitecan in Patients With Metastatic Triple-negative Breast Cancer (TNBC)
Start: Sep 19, 2025
Completion: Jul 1, 2030
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