Small Molecules
Total Trials
39
As Lead Sponsor
26
As Collaborator
13
Total Enrollment
4,143
NCT00115089
7 Day Study of Mast Cell Inhibitor, R926112, in Patients With Symptomatic Seasonal Allergic Rhinitis
Phase: Phase 2
Role: Lead Sponsor
Start: Jul 31, 2005
Completion: Sep 30, 2005
NCT00326339
Treatment of Arthritis With Syk Kinase Inhibition (TASKI-1)
Start: Aug 31, 2006
Completion: Dec 31, 2007
NCT00706342
Pilot Study of Fostamatinib Disodium/R935788 for the Treatment of Adult Refractory Immune Thrombocytopenic Purpura (ITP)
Start: Jan 31, 2007
Completion: Apr 30, 2010
NCT00446095
Efficacy and Safety Study of Fostamatinib Tablets to Treat B-cell Lymphoma
Phase: Phase 1/2
Start: Apr 30, 2007
Completion: Oct 31, 2010
NCT00665626
Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid Arthritis (Taski-3)
Start: May 31, 2008
Completion: Jun 30, 2009
NCT00665925
Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid Arthritis
NCT00752999
Efficacy and Safety Study of R935788 Tablets to Treat Systemic Lupus Erythematosus
Start: Nov 30, 2008
Completion: Mar 31, 2010
NCT00798096
Efficacy and Safety Study of Fostamatinib Disodium Tablets to Treat T-Cell Lymphoma
Start: Mar 31, 2009
NCT01591044
A Safety and Efficacy Study of Inhaled R940343 in Patients With Mild to Moderate Asthma
Start: Jul 31, 2012
Completion: Jul 31, 2013
NCT01597050
Safety and Efficacy of Topical R333 in Patients With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) Lesions
Start: Aug 31, 2012
Completion: Sep 30, 2013
NCT01733992
A Safety, Tolerability and Pharmacokinetics Study of R932348 Eye Drops in Patients With Dry Eye Disease
Phase: Phase 1
Start: Nov 30, 2012
Completion: Feb 28, 2013
NCT01900249
To Assess the Safety and Efficacy of R932348 Ophthalmic Solutions in Patients With Keratoconjunctivitis Sicca
Start: Jul 31, 2013
Completion: Jul 31, 2014
NCT02040623
Safety and Efficacy Study of R932348 Ophthalmic Solution in Chronic Ocular Graft Versus Host Disease Patients(DROPS-2)
Start: Mar 31, 2014
Completion: Jul 31, 2016
NCT02076399
A Efficacy and Safety Study of R935788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP)
Phase: Phase 3
Start: Jul 14, 2014
Completion: Apr 21, 2016
NCT02077192
Open Label Study of R788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP)
Start: Oct 31, 2014
Completion: Jun 2, 2020
NCT02112838
Safety and Efficacy Study of Fostamatinib to Treat Immunoglobin A (IgA) Nephropathy
Completion: Nov 12, 2018
NCT02076412
A Efficacy and Safety Study of Fostamatinib in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP)
Start: Jan 31, 2015
Completion: Aug 31, 2016
NCT02433236
Open Label Study of Fostamatinib in the Treatment of IgA Nephropathy
Start: Sep 30, 2015
Completion: Not specified
NCT02612558
A Safety and Efficacy Study of R935788 in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (AIHA)
Start: Jul 31, 2016
Completion: Dec 31, 2019
NCT03246074
Clinical Trial of Combined Fostamatinib and Paclitaxel in Ovarian Cancer
Role: Collaborator
Start: Apr 3, 2018
Completion: Apr 3, 2023
NCT03764618
A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of wAIHA
Start: Apr 24, 2019
Completion: Apr 11, 2022
NCT04138927
A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia
Start: Oct 30, 2019
Completion: Apr 30, 2024
NCT04581954
Inflammatory Signal Inhibitors for COVID-19 (MATIS)
Start: Oct 2, 2020
Completion: Jun 30, 2022
NCT04629703
Double-Blind, Randomized, Placebo-Controlled, Multi-Center Phase 3 Study to Evaluate the Efficacy and Safety of Fostamatinib in COVID-19 Subjects
Start: Mar 25, 2021
Completion: Sep 5, 2022
NCT04543279
Fostamatinib as a Single Agent or in Combination With Ruxolitinib for Treatment of Patients With Myelofibrosis With Severe Thrombocytopenia
Start: May 3, 2021
Completion: Jul 30, 2022
NCT04904276
Observational Study of Fostamatinib as Second Line Therapy in Adult Patients With Immune Thrombocytopenia (ITP) and Insufficient Response to a Prior Therapy
Phase: N/A
Start: May 18, 2021
Completion: Nov 17, 2022
NCT05040698
Study of the Effect of Fostamatinib Upon Cutaneous Inflammation in the Setting of Hidradenitis Suppurativa
Start: Oct 1, 2021
Completion: Jan 27, 2023
NCT05308264
Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS)
Start: Sep 12, 2022
Completion: Dec 31, 2026
NCT05848258
An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis
Start: May 23, 2023
Completion: Jul 31, 2026
NCT06639724
Perioperative Fostamatinib With Gemcitabine and Nab-paclitaxel in Resectable Pancreatic Cancer
Start: Dec 5, 2024
Completion: Dec 31, 2028
NCT06566742
A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.
Start: Dec 10, 2024
Completion: Aug 31, 2029
NCT06597734
A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm
Start: Jan 28, 2025
NCT06161974
Study of Olutasidenib and Temozolomide in HGG
Start: Mar 31, 2025
Completion: Jun 30, 2035
NCT07032727
Olutasidenib Combined With Co-targeted Therapy in Relapsed or Refractory IDH1-mutated Myeloid Malignancies Harboring Activated Signaling Pathway Mutations
Start: Sep 12, 2025
Completion: Jun 1, 2029
NCT06233110
Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD
Start: Oct 31, 2025
Completion: Jul 1, 2029
NCT07130695
Olutasidenib Single Plus Combo Therapy in IDH1mut AML After Induction and Consolidation
Completion: Oct 31, 2029
NCT06782542
Olutasidenib, Venetoclax, and Azacitidine in IDH1 Mutated Newly Diagnosed Acute Myeloid Leukemia Patients Eligible for Intensive Induction Chemotherapy
Start: Nov 1, 2025
Completion: Nov 1, 2028
NCT06564207
Fostamatinib for Treating Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Adults
Start: Nov 30, 2025
Completion: Oct 31, 2026
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