Drugs blocking the interaction between the ligand and its Dependence Receptor
Total Trials
7
As Lead Sponsor
1
As Collaborator
6
Total Enrollment
518
NCT02977195
First in Human Evaluation of Safety, Pharmacokinetics, and Clinical Activity of a Monoclonal Antibody Targeting Netrin 1 in Patients With Advanced/Metastatic Solid Tumors
Phase: Phase 1
Role: Collaborator
Start: Jan 9, 2017
Completion: Jun 30, 2022
NCT04652076
GYNecological Cancers Treated with NETrin MAbs in Combination with Chemotherapy and /or Pembrolizumab
Phase: Phase 1/2
Role: Lead Sponsor
Start: Dec 14, 2020
Completion: Jul 30, 2026
NCT05605496
NP137 Clinical and Biological Activities Assessment in Patients With Advanced/Metastatic Solid Tumors Treated by Standard Anti PD-1/PD-L1 Immunotherapies
Phase: Phase 2
Start: Jan 6, 2023
Completion: Nov 24, 2026
NCT05546879
Study Investigating the Association of NP137 With Atezolizumab-Bevacizumab Combination in First Line in Unresectable HCC
Start: Mar 15, 2023
Completion: Mar 15, 2027
NCT05546853
Study Investigating the Association of NP137 With mFOLFIRINOX in Locally Advanced Pancreatic Ductal Adenocarcinoma
Start: Mar 28, 2023
Completion: Jun 16, 2025
NCT06150040
Acute Myeloid Leukemia Treated With With NETrin Abs in Combination With [AZACITIDINE + VENETOCLAX]
Start: Sep 11, 2024
Completion: Feb 18, 2025
NCT06203821
Study of Perioperative NP137 and FOLFIRINOX in Resectable Pancreatic Cancer
Start: Sep 1, 2025
Completion: Dec 31, 2027
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