Epigenetics, Oncolytic viruses
Total Trials
16
As Lead Sponsor
As Collaborator
0
Total Enrollment
1,042
NCT01359982
Safety and Pharmacokinetic Study of RRx-001 in Cancer Subjects
Phase: Phase 1
Role: Lead Sponsor
Start: Sep 30, 2011
Completion: Feb 28, 2015
NCT02096341
A Phase 1 Pilot Study of the Subcutaneous (s.c.) Route to Facilitate the Administration of RRx-001
Start: Apr 30, 2014
Completion: Jan 31, 2016
NCT02096354
A Phase 2 Randomized, Open-Label Study of RRx-001 vs Regorafenib in Subjects With Metastatic Colorectal Cancer
Phase: Phase 2
Start: May 31, 2014
Completion: Oct 8, 2020
NCT02215512
Dose-Escalation Study of RRx-001 in Combination With Whole Brain Radiation in Subjects With Brain Metastases
Start: Feb 6, 2015
Completion: Nov 12, 2020
NCT02489903
RRx-001 in Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)
Start: Jun 30, 2015
Completion: Dec 6, 2021
NCT02452970
RRx-001 in Second Line Treatment of Advanced Cholangiocarcinoma Prior to Readministration of First-Line Therapy
Start: Jul 16, 2015
Completion: May 25, 2016
NCT02518958
A Phase I, Open-Label, Multiple Ascending Dose Study of RRx-001 and Nivolumab
Start: Jul 21, 2015
Completion: Sep 12, 2016
NCT02801097
RRx-001 in Combination With Irinotecan in Metastatic or Advanced Cancer (PAYLOAD)
Start: Aug 30, 2016
Completion: Dec 9, 2019
NCT02871843
RRx-001 + Radiation + Temozolomide In Newly Diagnosed Glioblastoma and Anaplastic Gliomas
Start: Feb 14, 2017
Completion: Sep 19, 2021
NCT03515538
Safety and Efficacy of RRx-001 in the Attenuation of Oral Mucositis in Patients Receiving Chemoradiation for the Treatment of Oral Cancers
Start: Jul 12, 2018
NCT03699956
RRx-001 Sequentially With a Platinum Doublet or a Platinum Doublet in Third-Line or Beyond in Patients With Small Cell Lung Cancer
Phase: Phase 3
Start: Dec 24, 2018
Completion: Mar 1, 2024
NCT04673942
A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors
Start: Mar 29, 2021
Completion: Mar 1, 2027
NCT05566041
A Phase 3, Controlled, Open-label, Global Randomized Study of RRx-001 With a Platinum Doublet or a Platinum Doublet in Small Cell Lung Cancer
Start: Aug 1, 2022
Completion: Dec 31, 2025
NCT04525014
RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors
Start: Jan 26, 2023
Completion: Jul 29, 2024
NCT05966194
RRx-001 for Reducing Oral Mucositis in Patients Receiving Chemotherapy and Radiation for Head and Neck Cancer
Start: Apr 2, 2024
Completion: Oct 1, 2025
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