Small Molecules, Biologics
Total Trials
20
As Lead Sponsor
17
As Collaborator
3
Total Enrollment
2,133
NCT00380653
Safety and Pharmacology Study of Sapacitabine to Treat Advanced Leukemias or Myelodysplastic Syndromes
Phase: Phase 1
Role: Lead Sponsor
Start: Jan 31, 2006
Completion: Jun 30, 2009
NCT00372073
Efficacy Study of Oral Seliciclib to Treat Non-Small Cell Lung Cancer
Phase: Phase 2
Start: Aug 9, 2006
Completion: Apr 7, 2009
NCT00476554
A Randomized Phase II Study of Oral Sapacitabine in Patients With Advanced Cutaneous T-cell Lymphoma
Start: Apr 30, 2007
Completion: Mar 1, 2012
NCT00560716
A Phase I Pharmacologic Study of CYC116, an Oral Aurora Kinase Inhibitor, in Patients With Advanced Solid Tumors
Start: Jun 30, 2007
Completion: Nov 30, 2009
NCT00590187
Efficacy Study of Oral Sapacitabine to Treat Acute Myeloid Leukemia in Elderly Patients
Start: Dec 31, 2007
Completion: Dec 1, 2018
NCT00885963
A Study of Oral Sapacitabine in Patients With Previously Treated Non-Small Cell Lung Cancer
Start: Dec 1, 2008
Completion: Dec 23, 2013
NCT00999401
A Study of Oral Sapacitabine and Oral Seliciclib in Patients With Advanced Solid Tumors
Start: Apr 30, 2009
Completion: Aug 13, 2019
NCT01211457
Study of Sapacitabine in Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS)
Phase: Phase 1/2
Start: Jun 17, 2010
Completion: Dec 31, 2020
NCT01253460
Sapacitabine, Cyclophosphamide, Rituximab for Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma (CLL/SLL) With Deletion (11q22-23)
Role: Collaborator
Start: Aug 22, 2011
Completion: Feb 13, 2019
NCT01303796
A Study of Oral Sapacitabine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia
Phase: Phase 3
Start: Oct 1, 2011
Completion: Jul 31, 2017
NCT02552953
A Pharmacologic Study of CYC065, a Cyclin Dependent Kinase Inhibitor, in Patients With Advanced Cancers
Start: Sep 28, 2015
Completion: Aug 25, 2023
NCT02649751
Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation
Start: Feb 22, 2016
Completion: Jul 26, 2018
NCT03641755
Olaparib + Sapacitabine in BRCA Mutant Breast Cancer
Start: Oct 1, 2018
Completion: Oct 22, 2025
NCT03739554
CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL
Start: Jan 25, 2019
Completion: Apr 27, 2023
NCT03884829
A Phase I Study of CYC140, a PLK-1 Inhibitor, in Advanced Leukemias or MDS
Start: Mar 25, 2019
Completion: Oct 19, 2023
NCT04017546
CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory AML or MDS
Start: Aug 2, 2019
Completion: Apr 5, 2023
NCT04983810
A Study to Investigate Fadraciclib (CYC065), in Subjects With Advanced Solid Tumors and Lymphoma
Start: Jul 12, 2021
Completion: Jun 30, 2025
NCT05168904
A Study to Investigate Fadraciclib (CYC065), in Subjects With Leukemia or Myelodysplastic Syndrome (MDS)
Start: Oct 22, 2021
Completion: Dec 31, 2024
NCT05358379
A Study to Investigate CYC140, in Subjects With Advanced Solid Tumors and Lymphoma
Start: Apr 14, 2022
Completion: Nov 30, 2025
NCT05817890
Absorption, Metabolism, and Excretion of CYC065 in Healthy Male Subjects
Phase: Early Phase 1
Start: Mar 3, 2023
Completion: May 22, 2024
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