CRISPR-Cas9 therapy
Total Trials
16
As Lead Sponsor
11
As Collaborator
5
Total Enrollment
1,325
NCT03655678
A Safety and Efficacy Study Evaluating CTX001 in Participants With Transfusion-Dependent β-Thalassemia
Phase: Phase 2/3
Role: Collaborator
Start: Sep 14, 2018
Completion: Dec 8, 2025
NCT03745287
A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease
Start: Nov 27, 2018
Completion: Jul 7, 2025
NCT04035434
A Safety and Efficacy Study Evaluating CTX110 in Subjects With Relapsed or Refractory B-Cell Malignancies (CARBON)
Phase: Phase 1/2
Role: Lead Sponsor
Start: Jul 22, 2019
Completion: Oct 4, 2024
NCT04244656
A Safety and Efficacy Study Evaluating CTX120 in Subjects With Relapsed or Refractory Multiple Myeloma
Phase: Phase 1
Start: Jan 22, 2020
Completion: Jan 4, 2024
NCT04438083
A Safety and Efficacy Study Evaluating CTX130 in Subjects With Relapsed or Refractory Renal Cell Carcinoma (COBALT-RCC)
Start: Jun 16, 2020
Completion: Oct 8, 2024
NCT04502446
A Safety and Efficacy Study Evaluating CTX130 in Subjects With Relapsed or Refractory T or B Cell Malignancies (COBALT-LYM)
Start: Jul 31, 2020
Completion: Aug 30, 2024
NCT04208529
A Long-term Follow-up Study in Participants Who Received CTX001
Phase: Phase 3
Start: Jan 20, 2021
Completion: Sep 30, 2039
NCT05210530
An Open-Label, FIH Study Evaluating the Safety and Tolerability of VCTX210A Combination Product in Subjects With T1D
Start: Jan 24, 2022
Completion: Jan 19, 2023
NCT05329649
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
Start: May 2, 2022
Completion: May 31, 2026
NCT05356195
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)
Start: May 3, 2022
NCT05565248
An Open-Label, FIH Study Evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects With T1D
Start: Jan 20, 2023
Completion: Aug 31, 2025
NCT05643742
A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies
Start: Mar 10, 2023
Completion: Feb 28, 2030
NCT05795595
A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors
Start: Mar 13, 2023
Completion: May 31, 2030
NCT06208878
A Long-term Follow-up Study of Subjects Who Received CRISPR CAR T Cellular Therapies
Phase: N/A
Start: Nov 22, 2023
Completion: Aug 31, 2038
NCT06492304
A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed/Refractory Hematologic Malignancies
Start: Aug 13, 2024
Completion: Nov 30, 2030
NCT06925542
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
Start: Mar 10, 2025
Completion: Dec 31, 2031
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