CNS treatments
Total Trials
34
As Lead Sponsor
30
As Collaborator
4
Total Enrollment
11,644
NCT02504008
CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1
Phase: Phase 3
Role: Lead Sponsor
Start: Jul 31, 2015
Completion: Jan 31, 2019
NCT02741791
A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Treatment Resistant Major Depressive Disorder
Start: Mar 31, 2016
Completion: Mar 20, 2020
NCT02746068
A Study to Assess the Efficacy and Safety of AXS-02 in Subjects With Knee OA Associated With Bone Marrow Lesions
Completion: Dec 31, 2020
NCT03226522
Addressing Dementia Via Agitation-Centered Evaluation
Phase: Phase 2/3
Start: Jul 13, 2017
Completion: Apr 17, 2020
NCT03471767
AXS-05 Phase II Trial on Smoking Behavior
Phase: Phase 2
Role: Collaborator
Start: Mar 25, 2018
Completion: Mar 31, 2019
NCT03595579
Assessing Symptomatic Clinical Episodes in Depression
Start: May 30, 2018
Completion: Jan 7, 2019
NCT03881852
Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT)
Start: Jan 30, 2019
Completion: Nov 27, 2019
NCT03896009
Maximizing Outcomes in Treating Acute Migraine
Start: Mar 4, 2019
Completion: Dec 10, 2019
NCT04019704
A Trial of AXS-05 in Patients With Major Depressive Disorder
Start: Jun 20, 2019
Completion: Dec 5, 2019
NCT04068051
Multimechanistic Treatment Over Time of Migraine Symptoms (MOVEMENT)
Start: Jul 6, 2019
Completion: Sep 22, 2020
NCT04039022
Open-Label Safety Study of AXS-05 in Subjects With Depression
Start: Jul 8, 2019
Completion: Oct 23, 2020
NCT06413420
SUNOSI® (Solriamfetol) Pregnancy Registry
Phase: N/A
Start: Jul 31, 2019
Completion: Sep 30, 2029
NCT04163185
Initiating Early Control of Migraine Pain and Associated Symptoms
Start: Oct 8, 2019
Completion: Mar 23, 2020
NCT04608396
Mechanistic Evaluation of Response in TRD (MERIT)
Start: Aug 13, 2020
Completion: Jul 30, 2021
NCT04634669
Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE)
Start: Sep 23, 2020
Completion: Mar 4, 2022
NCT04797715
Assessing Clinical Outcomes in Alzheimer's Disease Agitation
Start: Dec 31, 2020
Completion: Nov 21, 2022
NCT04971291
An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent Patients
Start: Apr 14, 2021
Completion: Jul 31, 2021
NCT04789174
Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study
Phase: Phase 4
Start: May 17, 2021
Completion: Sep 19, 2022
NCT04947553
A Study to Assess the Long-term Safety and Efficacy of AXS-05 in Subjects With Alzheimer's Disease Agitation
Start: Jun 17, 2021
Completion: Dec 21, 2024
NCT04788953
Clinical Trial of Solriamfetol for Excessive Sleepiness Related to Shift Work Disorder
Start: Jul 21, 2021
Completion: Apr 19, 2024
NCT05008341
Evaluate Sunosi® PK in Breast Milk and Plasma of Healthy Postpartum Women Following Single Dose Oral Administration
Phase: Phase 1
Start: Aug 27, 2021
Completion: Apr 15, 2022
NCT05059223
A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy
Start: Sep 15, 2021
Completion: Mar 15, 2024
NCT05113745
A Study to Assess the Long-term Efficacy and Safety of AXS-12 (Reboxetine) in Subjects with Narcolepsy (ENCORE)
Start: Oct 20, 2021
Completion: Nov 15, 2024
NCT05550207
Open-Label Study of AXS-07 for the Acute Treatment of Migraine in Adults With a Prior Inadequate Response to an Oral CGRP Inhibitor (EMERGE)
Start: Aug 31, 2022
Completion: Nov 27, 2024
NCT05557409
A Study to Assess the Efficacy and Safety of AXS-05 in Subjects with Alzheimer's Disease Agitation
Start: Sep 6, 2022
NCT05972044
A Study to Assess the Efficacy and Safety of Solriamfetol in Subjects With ADHD (FOCUS)
Start: Jul 6, 2023
Completion: Mar 14, 2025
NCT05838430
Solriamfetol and CBT-I in Patients With Insomnia Disorder
Start: Jul 31, 2023
Completion: Apr 30, 2026
NCT06223880
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
Start: Dec 27, 2023
Completion: Mar 31, 2026
NCT06360419
Progressing TAAR-1, Dopamine, and Norepinephrine in Depression Using Solriamfetol
Start: Mar 18, 2024
Completion: Mar 26, 2025
NCT06413433
Elucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using Solriamfetol
Start: Apr 26, 2024
Completion: Dec 31, 2025
NCT06170970
Solriamfetol for the Treatment of Multiple Sclerosis Fatigue
Start: Jun 1, 2024
Completion: Mar 1, 2027
NCT06568367
Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)
Start: Aug 1, 2024
Completion: Dec 31, 2026
NCT06736509
An Open-Label Study to Assess the Long-term Safety of AXS-05 in Subjects With Dementia of the Alzheimer's Type, ADVANCE-2 and ACCORD-2 Extension Study
Start: Nov 21, 2024
Completion: Apr 25, 2025
NCT06878976
Open-Label Safety Study of Solriamfetol in Subjects with Binge Eating Disorder
Start: Feb 20, 2025
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