Gastrointestinal Therapeutics
Total Trials
31
As Lead Sponsor
28
As Collaborator
3
Total Enrollment
6,140
NCT02819687
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RDX5791 in Healthy Volunteers
Phase: Phase 1
Role: Lead Sponsor
Start: Nov 30, 2010
Completion: Aug 31, 2011
NCT01340053
A Study to Evaluate the Safety and Efficacy of RDX5791 for the Treatment of Constipation Predominant Irritable Bowel Syndrome (IBS-C)
Phase: Phase 2
Start: May 31, 2011
Completion: Feb 29, 2012
NCT02796131
Safety, Tolerability, and Pharmacodynamics of RDX5791 in Healthy Volunteers
Start: Jul 31, 2011
Completion: Apr 30, 2012
NCT01764854
Pharmacodynamic Study of AZD1722 in End-stage Renal Disease Patients on Hemodialysis
Start: Jan 31, 2013
Completion: Oct 31, 2013
NCT02249936
A Phase 1 Study to Examine the Pharmacodynamics of Different AZD1722 Formulations
Start: Feb 28, 2013
Completion: Feb 28, 2013
NCT02226783
D5611C00003 - Food Interaction Study With AZD1722 Tablet in Healthy Subjects
Start: Mar 31, 2013
NCT02346890
A Phase 1 Study to Examine the Effect of Renvela on the Pharmacodynamics of AZD1722
Start: Apr 30, 2013
Completion: Apr 30, 2013
NCT01847092
A Study in CKD Patients With Type 2 Diabetes Mellitus and Albuminuria
Start: May 31, 2013
Completion: Apr 30, 2015
NCT02176252
Safety, Tolerability, Pharmacokinetics and Pharmacodynamic of AZD1722 in Healthy Male and Female Japanese Subjects
Start: Jul 31, 2013
Completion: Dec 31, 2013
NCT01923428
The Efficacy of AZD1722 in Constipation Predominant Irritable Bowel Syndrome (IBS-C)
Phase: Phase 2/3
Start: Aug 31, 2013
Completion: Oct 31, 2014
NCT02081534
Dose Finding Study to Treat High Phosphate Levels in the Blood.
Start: Mar 31, 2014
Completion: Nov 30, 2014
NCT02063386
AZD1722 Open Label, Absorption Distribution Metabolism and Excretion Study
Start: Apr 30, 2014
Completion: May 31, 2014
NCT02140268
To Evaluate the Effect of AZD1722 on the Pharmacokinetics of Oral Midazolam in Healthy Volunteers
Start: May 31, 2014
Completion: Aug 31, 2014
NCT02140281
To Assess the Effect of AZD1722 on the Pharmacokinetics of Cefadroxil in Healthy Volunteers
NCT02621892
A 12-Week Study With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Tenapanor for the Treatment of IBS-C
Phase: Phase 3
Start: Oct 31, 2015
Completion: Apr 30, 2017
NCT02686138
A 26-Week Study to Evaluate the Efficacy and Safety of Tenapanor in IBS-C
Start: Dec 31, 2015
Completion: Oct 31, 2017
NCT02675998
An 8-Week Study to Evaluate Tenapanor in the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients on Hemodialysis (ESRD-HD)
Start: Jan 31, 2016
Completion: Jan 17, 2018
NCT02727751
A Long-Term Safety Study of Tenapanor for the Treatment of IBS-C
Start: Mar 31, 2016
NCT03018067
A Study Evaluating the Onset-of-Action, Safety, and Efficacy of RDX227675 for the Treatment of Hyperkalemia
Start: Jan 31, 2017
Completion: May 31, 2017
NCT03427125
A Phase 3 Study of Tenapanor to Treat Hyperphosphatemia in ESRD Patients on Dialysis
Start: Jan 8, 2018
Completion: Feb 27, 2020
NCT03824587
Study to Evaluate the Efficacy of Tenapanor as Adjunctive Therapy to Phosphate Binder Therapy
Start: Feb 28, 2019
Completion: Jul 17, 2019
NCT03988920
A Long-Term Study of Tenapanor Alone or in Combination With Sevelamer in Patients With CKD on Dialysis and HP
Phase: Phase 4
Start: Jun 15, 2019
Completion: Jul 31, 2021
NCT04549597
Study to Evaluate the Use of Tenapanor as Core Therapy in the Treatment of Hyperphosphatemia
Start: Nov 20, 2020
Completion: Dec 1, 2021
NCT04780841
A Study Evaluating the Safety and Efficacy of RDX013 for the Treatment of Hyperkalemia
Start: Jan 11, 2021
Completion: Mar 3, 2022
NCT05643534
Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years
Start: Nov 15, 2022
Completion: Dec 31, 2025
NCT05905926
Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C
Start: Feb 17, 2023
Completion: Oct 31, 2031
NCT06203444
An Open-label Study to Evaluate the Pharmacokinetics of Oral Tenapanor in Breast Milk of Lactating Females
Start: Nov 27, 2023
Completion: May 30, 2024
NCT05995899
Effect of Tenapanor on the Metagenomics and Metabolomics of Patients With Irritable Bowel Syndrome With Constipation
Role: Collaborator
Start: Feb 6, 2024
Completion: Oct 31, 2025
NCT06553547
4-Week, Multi-center Dose-Ranging Study for the IBS-C in Pts. 6 to <12 Yrs
Start: Jul 24, 2024
Completion: Jun 30, 2026
NCT06460038
Tenapanor in Synucleinopathy-Related Constipation
Start: Jan 1, 2025
Completion: Mar 31, 2027
NCT06810167
Assessing Tenapanor as a Treatment of CF-related Constipation.
Start: Jun 1, 2025
Completion: Jun 30, 2027
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